دورية أكاديمية
Is Desmopressin Useful in the Evaluation of Cushing Syndrome?
| العنوان: | Is Desmopressin Useful in the Evaluation of Cushing Syndrome? |
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| المؤلفون: | Castinetti, Frederic, Lacroix, André |
| المساهمون: | Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Marseille Maladies Rares (MarMaRa), Aix Marseille Université (AMU), Service d'endocrinologie, diabète, maladies métaboliques Hôpital de la Conception - APHM, Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM) |
| المصدر: | ISSN: 0021-972X. |
| بيانات النشر: | HAL CCSD Endocrine Society |
| سنة النشر: | 2022 |
| المجموعة: | Aix-Marseille Université: HAL |
| مصطلحات موضوعية: | Cushing syndrome, Cushing disease, CRH, bilateral inferior petrosal sinus sampling, hypercortisolism, recurrence, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism |
| الوصف: | International audience ; The desmopressin test was first described 30 years ago. Based on the differential secretagogue properties of desmopressin on adrenocorticotropin (ACTH) release between normal and corticotroph tumor cells, this test was intended to facilitate the diagnosis of Cushing syndrome (CS). The distinct expression of the various arginine vasopressin receptors between normal pituitary, corticotroph tumors, or neuroendocrine tumors cells secreting ACTH ectopically suggested that this test could facilitate the etiological diagnosis of ACTH-dependent CS. In this review, we analyze the merits and pitfalls of desmopressin use in the diagnostic procedures of CS. Desmopressin response is not able to completely differentiate the various etiologies of CS; its wider availability has allowed its use for inferior petrosal sinus sampling confirmation of a pituitary source of ACTH excess. In addition, desmopressin can be useful to demonstrate adequate corticotroph tumor resection when its stimulatory effect is lost following pituitary surgery of patients with Cushing disease. Desmopressin response can also be a marker of the risk of longer-term postoperative recurrence. However, this review also highlights the lack of consensual criteria of normal or abnormal response to desmopressin in its various uses and requirement for further research on its usefulness. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04039475; https://amu.hal.science/hal-04039475Test; https://amu.hal.science/hal-04039475/documentTest; https://amu.hal.science/hal-04039475/file/jc.2022-01537.pdfTest |
| DOI: | 10.1210/clinem/dgac533 |
| الإتاحة: | https://doi.org/10.1210/clinem/dgac533Test https://amu.hal.science/hal-04039475Test https://amu.hal.science/hal-04039475/documentTest https://amu.hal.science/hal-04039475/file/jc.2022-01537.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.63393BF6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1210/clinem/dgac533 |
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