دورية أكاديمية
Ocular sequelae of epidermal necrolysis: French national audit of practices, literature review and proposed management
| العنوان: | Ocular sequelae of epidermal necrolysis: French national audit of practices, literature review and proposed management |
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| المؤلفون: | Thorel, Dhyna, Ingen-Housz-Oro, Saskia, Benaïm, Daniel, Daien, Vincent, Gabison, Eric, Saunier, Valentine, Béral, Laurence, Touboul, David, Brémond-Gignac, Dominique, Robert, Matthieu, Vasseur, Robin, Royer, Gérard, Dereure, Olivier, Milpied, Brigitte, Bernier, Claire, Welfringer-Morin, Anne, Bodemer, Christine, Cordel, Nadège, Tauber, Marie, Burillon, Carole, Servant, Marion, Couret, Chloe, Vabres, Bertrand, Tétart, Florence, Cassagne, Myriam, Kuoch, Marie-Ange, Muraine, Marc, Delcampe, Agnès, Gueudry, Julie |
| المساهمون: | Epidemiology in Dermatology and Evaluation in Therapeutics (EpiDermE), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-Etablissement français du don du sang Montpellier -Université de Montpellier (UM) |
| المصدر: | ISSN: 1750-1172 ; Orphanet Journal of Rare Diseases ; https://hal.science/hal-04099619Test ; Orphanet Journal of Rare Diseases, 2023, 18 (1), pp.51. ⟨10.1186/s13023-023-02616-6⟩. |
| بيانات النشر: | HAL CCSD BioMed Central |
| سنة النشر: | 2023 |
| المجموعة: | Université des Antilles (UAG): HAL |
| مصطلحات موضوعية: | [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology |
| الوصف: | International audience ; Abstract Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious and rare diseases, most often drug-induced, and their incidence has been estimated at 6 cases/million/year in France. SJS and TEN belong to the same spectrum of disease known as epidermal necrolysis (EN). They are characterized by more or less extensive epidermal detachment, associated with mucous membrane involvement, and may be complicated during the acute phase by fatal multiorgan failure. SJS and TEN can lead to severe ophthalmologic sequelae. There are no recommendations for ocular management during the chronic phase. We conducted a national audit of current practice in the 11 sites of the French reference center for toxic bullous dermatoses and a review of the literature to establish therapeutic consensus guidelines. Ophthalmologists and dermatologists from the French reference center for epidermal necrolysis were asked to complete a questionnaire on management practices in the chronic phase of SJS/TEN. The survey focused on the presence of a referent ophthalmologist at the center, the use of local treatments (artificial tears, corticosteroid eye drops, antibiotic-corticosteroids, antiseptics, vitamin A ointment (VA), cyclosporine, tacrolimus), the management of trichiatic eyelashes, meibomian dysfunction, symblepharons, and corneal neovascularization, as well as the contactologic solutions implemented. Eleven ophthalmologists and 9 dermatologists from 9 of the 11 centers responded to the questionnaire. Based on questionnaire results, 10/11 ophthalmologists systematically prescribed preservative-free artificial tears, and 11/11 administered VA. Antiseptic or antibiotic eye drops or antibiotic-corticosteroid eye drops were recommended as needed by 8/11 and 7/11 ophthalmologists, respectively. In case of chronic inflammation, topical cyclosporine was consistently proposed by 11/11 ophthalmologists. The removal of trichiatic eyelashes was mainly performed by 10/11 ophthalmologists. Patients were ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04099619; https://hal.science/hal-04099619Test; https://hal.science/hal-04099619/documentTest; https://hal.science/hal-04099619/file/s13023-023-02616-6.pdfTest |
| DOI: | 10.1186/s13023-023-02616-6 |
| الإتاحة: | https://doi.org/10.1186/s13023-023-02616-6Test https://hal.science/hal-04099619Test https://hal.science/hal-04099619/documentTest https://hal.science/hal-04099619/file/s13023-023-02616-6.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.62D30BD2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13023-023-02616-6 |
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