رسالة جامعية
Development of a non-invasive procedure for the dosage of macrocyclic lactones drugs in the skin in the scabies porcine model ; Développement d’une technique de dosage cutané non invasive des lactones macrocycliques dans le modèle porcin de la gale
| العنوان: | Development of a non-invasive procedure for the dosage of macrocyclic lactones drugs in the skin in the scabies porcine model ; Développement d’une technique de dosage cutané non invasive des lactones macrocycliques dans le modèle porcin de la gale |
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| المؤلفون: | Jannic, Arnaud |
| المساهمون: | Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Charlotte Bernigaud |
| المصدر: | https://dumas.ccsd.cnrs.fr/dumas-01904904Test ; Médecine humaine et pathologie. 2018. |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2018 |
| المجموعة: | DUMAS (Dépôt Universitaire de Mémoires Après Soutenance) |
| مصطلحات موضوعية: | Moxidectin, Gale, Modèle animal, Stratum corneum, Lactones macrocycliques, Ivermectine, Moxidectine, MESH: Scabies, MESH: Models, Animal, MESH: Macrocyclic lactones, MESH: Ivermectin, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | Human scabies remains a major health problem worldwide but suitable therapeutics are still lacking. The development of an experimental pig model of scabies allowed the evaluation of new treatments, notably molecules from the macrocyclic lactone family. The aim of the study was to develop a non-invasive procedure for the detection and the dosage of moxidectin (MOX) and ivermectin (IVM) in the skin to extend the drugs cutaneous pharmacokinetics data. Four pigs received simultaneously MOX (0.3 mg/kg at day 0) and IVM (0.2 mg/kg at days 0 and 8) both orally. Blood samples, skin biopsies and stratum corneum samples collected with adhesive discs were realized for 11 days post-treatment. Stratum corneum quantification was performed by three different methods. MOX and IVM were dosed in each sample. The MOX pharmacokinetic profile was similar in the skin and in the stratum corneum with a peak at day 1 and then a progressive decline. Values obtained with both methods were positively correlated. The IVM pharmacokinetic profile was similar to MOX profile in the skin with lower concentrations although its distribution in the stratum corneum was different with a plateau reached at day 2. Adhesive discs samples standardisation and quantification should be improved. Differences between the two drugs distribution in the skin and in the stratum corneum have now to be studied with humans. ; La gale demeure un enjeu majeur de santé publique et les possibilités thérapeutiques sont insuffisantes. La mise en place d’un modèle porcin de la gale a permis l’évaluation de nouveaux traitements, notamment des molécules de la famille des lactones macrocycliques. L’objectif de cette étude était d’optimiser le modèle porcin par le développement d’une technique non invasive de dosage cutané de la moxidectine (MOX) et de l’ivermectine (IVM) afin de faciliter et d’approfondir les données de pharmacologie cutanée. Quatre porcs ont reçu simultanément de la MOX orale (0,3 mg/kg à J0) et de l’IVM orale (0,2 mg/kg à J0 et J8). Des prélèvements ... |
| نوع الوثيقة: | master thesis |
| اللغة: | French |
| العلاقة: | dumas-01904904; https://dumas.ccsd.cnrs.fr/dumas-01904904Test; https://dumas.ccsd.cnrs.fr/dumas-01904904/documentTest; https://dumas.ccsd.cnrs.fr/dumas-01904904/file/ThExe_JANNIC_Arnaud_DUMAS.pdfTest |
| الإتاحة: | https://dumas.ccsd.cnrs.fr/dumas-01904904Test https://dumas.ccsd.cnrs.fr/dumas-01904904/documentTest https://dumas.ccsd.cnrs.fr/dumas-01904904/file/ThExe_JANNIC_Arnaud_DUMAS.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-ndTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.62C4EB1F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |