دورية أكاديمية
Association of Alzheimer's disease GWAS loci with MRI markers of brain aging
| العنوان: | Association of Alzheimer's disease GWAS loci with MRI markers of brain aging |
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| المؤلفون: | Chauhan, G. (Ganesh), Adams, H.H.H. (Hieab), Bis, J.C. (Joshua), Weinstein, G. (Galit), Yu, L. (Lei), Töglhofer, A.M. (Anna Maria), Smith, A.V. (Davey), Lee, S.J. (Sven) van der, Gottesman, R.F. (Rebecca), Thomson, R. (Russell), Wang, J. (Jing), Yang, Q. (Qiong Fang), Niessen, W.J. (Wiro), Lopez, O.L. (Oscar), Becker, J.T. (James), Phan, T.G. (Thanh), Beare, R.J. (Richard), Arfanakis, K. (Konstantinos), Fleischman, D. (Debra), Vernooij, M.W. (Meike), Mazoyer, B. (Bernard), Schmidt, R. (Reinhold), Srikanth, V. (Velandai), Knopman, D.S. (David), Jack Jr., C.R. (Clifford), Amouyel, P. (Philippe), Hofman, A. (Albert), DeCarli, C. (Charles), Tzourio, C. (Christophe), Duijn, C.M. (Cornelia) van, Bennett, D.A. (David), Longstreth Jr, W.T., Mosley, T.H. (Thomas H.), Fornage, M. (Myriam), Launer, L.J. (Lenore), Seshadri, S. (Sudha), Ikram, M.A. (Arfan), Debette, S. (Stéphanie) |
| المصدر: | Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology vol. 36 no. 4, pp. 1765.e7-1765.e16 |
| سنة النشر: | 2015 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: | Alzheimer, Genetic risk score, GWAS, Hippocampal volume, MRI-Markers |
| الوصف: | Whether novel risk variants of Alzheimer's disease (AD) identified through genome-wide association studies also influence magnetic resonance imaging-based intermediate phenotypes of AD in the general population is unclear. We studied association of 24 AD risk loci with intracranial volume, total brain volume, hippocampal volume (HV), white matter hyperintensity burden, and brain infarcts in a meta-analysis of genetic association studies from large population-based samples (N= 8175-11,550). In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (. p= 0.0054) and CD33 (rs3865444) with smaller intracranial volume (. p= 0.0058). In gene-based tests, there was associations of HLA-DRB1 with total brain volume (. p= 0.0006) and BIN1 with HV (. p= 0.00089). Aweighted AD genetic risk score was associated with smaller HV (beta ± SE=-0.047 ± 0.013, p= 0.00041), even after excluding the APOE locus (. p= 0.029). However, only association of AD genetic risk score with HV, including APOE, was significant after multiple testing correction (including number of independent phenotypes tested). These results suggest that novel AD genetic risk variants may contribute to structural brain aging in nondemented older community persons. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://repub.eur.nl/pub/90568Test; urn:hdl:1765/90568 |
| DOI: | 10.1016/j.neurobiolaging.2014.12.028 |
| الإتاحة: | https://doi.org/10.1016/j.neurobiolaging.2014.12.028Test http://repub.eur.nl/pub/90568Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.62B7C2B5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.neurobiolaging.2014.12.028 |
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