دورية أكاديمية
One-year clinical outcome of biodegradable polymer sirolimus-eluting stent in patients needing short dual antiplatelet therapy. Insight from the ULISSE registry (ULtimaster Italian multicenter all comerS Stent rEgistry)
| العنوان: | One-year clinical outcome of biodegradable polymer sirolimus-eluting stent in patients needing short dual antiplatelet therapy. Insight from the ULISSE registry (ULtimaster Italian multicenter all comerS Stent rEgistry) |
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| المؤلفون: | Godino, Cosmo, Beneduce, Alessandro, Ferrante, Giuseppe, Ielasi, Alfonso, Pivato, Carlo Andrea, Chiarito, Mauro, Cappelletti, Alberto, Perfetti, Giulia, Magni, Valeria, Prati, Eugenio, Falcone, Stefania, Pierri, Adele, De Martini, Stefano, Montorfano, Matteo, Parisi, Rosario, Rutigliano, David, Locuratolo, Nicola, Anzuini, Angelo, Tespili, Maurizio, Margonato, Alberto, Benassi, Alberto, Briguori, Carlo, Fabbiocchi, Franco, Reimers, Bernhard, Bartorelli, Antonio, Colombo, Antonio |
| المساهمون: | Godino, Cosmo, Beneduce, Alessandro, Ferrante, Giuseppe, Ielasi, Alfonso, Pivato, Carlo Andrea, Chiarito, Mauro, Cappelletti, Alberto, Perfetti, Giulia, Magni, Valeria, Prati, Eugenio, Falcone, Stefania, Pierri, Adele, De Martini, Stefano, Montorfano, Matteo, Parisi, Rosario, Rutigliano, David, Locuratolo, Nicola, Anzuini, Angelo, Tespili, Maurizio, Margonato, Alberto, Benassi, Alberto, Briguori, Carlo, Fabbiocchi, Franco, Reimers, Bernhard, Bartorelli, Antonio, Colombo, Antonio |
| بيانات النشر: | Elsevier Ireland Ltd |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Biodegradable polymer sirolimus-eluting stent, Dual antiplatelet therapy, High bleeding risk, Percutaneous coronary intervention, Stent thrombosi, Cardiology and Cardiovascular Medicine |
| الوصف: | Background: This study aimed to evaluate real-world clinical outcome of patients needing short dual antiplatelet therapy (S-DAPT) following PCI with Ultimaster® thin-strut, biodegradable polymer sirolimus-eluting stent (BP-SES), which was supposed to induce faster stent endothelialization and reduce device thrombogenicity. Methods: In this sub-group analysis of patients enrolled in the ULISSE registry, two groups were identified: 1) patients discharged with S-DAPT (≤3-month) due to high bleeding risk or need for urgent major non-cardiac surgery and 2) patients discharged with recommended DAPT (R-DAPT) duration (≥6-month). The primary ischemic-safety and bleeding-safety endpoints were TLF (composite of cardiac-death, target vessel MI, and clinically driven target lesion revascularization), and BARC major bleedings (≥type-3a) at 1-year follow-up. To account for events occurring before DAPT discontinuation we performed 3-month landmark analysis. Results: 82 patients (5%) were discharged with ≤3-month DAPT (57 ± 27 days), and 1558 patients (94%) were discharged with ≥6-month DAPT (318 ± 75 days). No significant differences between S-DAPT and R-DAPT group were observed in TLF at 1-year (7.9% vs. 4.6%). The rate of BARC major bleeding resulted significantly higher in S-DAPT group (3.9% vs. 0.3%; p = 0.001), with the majority of bleeding events occurring within 3 months. The landmark analysis showed no significant differences in BARC major bleedings between groups (1.4% vs. 0.3%; p = 0.142). Conclusions: As compared to those treated with R-DAPT (≥6-month), patients needing -S-DAPT (≤3-month) after PCI with Ultimaster® BP-SES had similar rates of 1-year TLF and BARC major bleedings following early DAPT discontinuation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000470826500010; journal:INTERNATIONAL JOURNAL OF CARDIOLOGY; http://hdl.handle.net/20.500.11768/87592Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85063144208; www.elsevier.com/locate/ijcard |
| DOI: | 10.1016/j.ijcard.2019.03.030 |
| الإتاحة: | https://doi.org/20.500.11768/87592Test https://doi.org/10.1016/j.ijcard.2019.03.030Test https://hdl.handle.net/20.500.11768/87592Test |
| رقم الانضمام: | edsbas.6296CB70 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ijcard.2019.03.030 |
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