دورية أكاديمية
P1773Predictors of arrhythmic events in patients with non-compaction cardiomyopathy
| العنوان: | P1773Predictors of arrhythmic events in patients with non-compaction cardiomyopathy |
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| المؤلفون: | Vaikhanskaya, T, Kurushka, T V, Sivitskaya, L N |
| المصدر: | European Heart Journal ; volume 40, issue Supplement_1 ; ISSN 0195-668X 1522-9645 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine |
| الوصف: | The phenotypic expression of non-compaction cardiomyopathy (NCM) ranges from subclinical arrhythmias to sudden cardiac death. Objective Search of identifying predictors of life-threatening ventricular tachyarrhythmias (ltVTA) and analysis arrhythmic risk stratification capacity of ECG (heart rate turbulence – HRT, microvolt T-wave alternans – mTWA, QT interval corrected - QTc, and fragmented QRS - frQRS), Echo and MRI features in pts with NCM was the goal of this study. Methods The study enrolled and followed up 59,7±16,2 months 72 pts (family – 13; sporadic – 59; aged 39.2±14.1 years; 43/59.7% male; LVEF 44.7±13.2%) with morphological signs of non-compaction myocardium, confirmed by any three of the four standart criteria: Echo (Jenni, Stöllberger), MRI (Petersen, Jacquier). For analysis as primary end-points the following ltVTA events were accepted: SCD, successful resuscitation, stVT/VF/syncope, appropriated ICD discharges. Results As a result of the rank correlation Spearman analysis positive correlations (p<0.0001) of an MRI markers of myocardial fibrosis were revealed with ECG parameters; thus, leads (n) with frQRS (frQRSn: r=0.65) and QT interval corrected (QTc: r=0.66) correlated with T1 native relaxation time (ms) and the LGE myocardial segments (n). Significant correlations (p<0.0005) are found between LGE (%) and frQRS(n): r=0.61; QTc: r=0.56; VTA (r=0.48); systolic dysfunction (LVEF: r=−0.59; GLS: r=0.58; TAPSE: r=−0.55; RVEF: r=−0.54) and biventricular non-compaction (r=0.60). Positive correlations of the frQRS(n) with the pathological mTWA test (mTWA mean: r=0.55; p<0.001), VTA (r=0.61; p=0.0008) and negative correlations with systolic/contractile function (LVEF: r=−0.56, p=0.001; TAPSE: r=−0.51, p=0.003; LV GLS “–”%: r=−0.57, p<0.001) were determined. Surprisingly, significant correlations between NC/C ratio (one of the main diagnostic criteria of LVNC) and other phenotypic signs or clinical complications were not identified. As a result of step-by-step multiple regression ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/eurheartj/ehz748.0525 |
| الإتاحة: | https://doi.org/10.1093/eurheartj/ehz748.0525Test http://academic.oup.com/eurheartj/article-pdf/40/Supplement_1/ehz748.0525/30202495/ehz748.0525.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.626BEA4C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/eurheartj/ehz748.0525 |
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