دورية أكاديمية
Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response
| العنوان: | Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response |
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| المؤلفون: | Roller, Devin G., Hoang, Stephen A., Rawls, Kristopher D., Owen, Katherine A., Simmers, Michael B., Figler, Robert A., Wulfkuhle, Julia D., Petricoin, Emanuel F., Wamhoff, Brian R., Gioeli, Daniel |
| المساهمون: | National Cancer Institute |
| المصدر: | Scientific Reports ; volume 11, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Multidisciplinary |
| الوصف: | Lung cancer rates are rising globally and non-small cell lung cancer (NSCLC) has a five year survival rate of only 24%. Unfortunately, the development of drugs to treat cancer is severely hampered by the inefficiency of translating pre-clinical studies into clinical benefit. Thus, we sought to apply a tumor microenvironment system (TMES) to NSCLC. Using microvascular endothelial cells, lung cancer derived fibroblasts, and NSCLC tumor cells in the presence of in vivo tumor-derived hemodynamic flow and transport, we demonstrate that the TMES generates an in-vivo like biological state and predicts drug response to EGFR inhibitors. Transcriptomic and proteomic profiling indicate that the TMES recapitulates the in vivo and patient molecular biological state providing a mechanistic rationale for the predictive nature of the TMES. This work further validates the TMES for modeling patient tumor biology and drug response indicating utility of the TMES as a predictive tool for drug discovery and development and potential for use as a system for patient avatars. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-021-84612-z |
| الإتاحة: | https://doi.org/10.1038/s41598-021-84612-zTest https://www.nature.com/articles/s41598-021-84612-z.pdfTest https://www.nature.com/articles/s41598-021-84612-zTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.626A1228 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-021-84612-z |
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