التفاصيل البيبلوغرافية
| العنوان: |
Evaluation of the coordinated actions of estrogen receptors with epidermal growth factor receptor and insulin‐like growth factor receptor in the expression of cell surface heparan sulfate proteoglycans and cell motility in breast cancer cells |
| المؤلفون: |
Tsonis, Anastasios I., Afratis, Nikolaos, Gialeli, Chrisostomi, Ellina, Maria‐Ioanna, Piperigkou, Zoi, Skandalis, Spyridon S., Theocharis, Achilleas D., Tzanakakis, George N., Karamanos, Nikos K. |
| المصدر: |
The FEBS Journal ; volume 280, issue 10, page 2248-2259 ; ISSN 1742-464X 1742-4658 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2013 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Estradiol (E2)–estrogen receptor ( ER ) actions are implicated in initiation, growth and progression of hormone‐dependent breast cancer. Crosstalk between ER s, epidermal growth factor receptor ( EGFR ) and/or insulin‐like growth factor receptor ( IGFR ) is critical for the observed resistance to endocrine therapies. Cell surface heparan sulfate proteoglycans ( HSPG s) are principal mediators of cancer cell properties and the E2– ER pathway as well as those activated by EGFR and IGFR have significant roles in regulating the expression of certain cell surface HSPG s, such as syndecan‐2 ( SDC ‐2), syndecan‐4 ( SDC ‐4) and glypican‐1. In this study, we therefore evaluated the role of EGFR ‐ IGFR signaling on the constitutive expression and E2‐mediated expression of ER s and HSPG s as well as the effect of E2– ER s and IGFR / EGFR ‐mediated cell migration in ER α+ ( MCF ‐7) and ER β+ ( MDA ‐ MB ‐231) breast cancer cells using specific intracellular inhibitors of EGFR and IGFR . We report that the expression of ER α is mainly enhanced by IGFR , whereas ER β expression is mainly coordinated by EGFR . Moreover, constitutive SDC ‐2 expression in ER α+ and ER β+ cells is mainly mediated through the IGFR , whereas in ER α+ E2‐treated cells EGFR is the active one. In contrast, SDC ‐4 expression is regulated by IGFR in the presence and absence of E2. E2 also seems to diminish the inhibitory effect of EGFR and IGFR inhibitors in breast cancer cell migration. These data suggest that the coordinated action of ER s with EGFR and/or IGFR is of crucial importance, providing potential targets for designing and developing novel multi‐potent agents for endocrine therapies. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/febs.12162 |
| الإتاحة: |
https://doi.org/10.1111/febs.12162Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.62506228 |
| قاعدة البيانات: |
BASE |
