التفاصيل البيبلوغرافية
| العنوان: |
Image_10_Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients.png |
| المؤلفون: |
Stéphanie Bibert (3279381), Nicolas Guex (117459), Joao Lourenco (10898868), Thomas Brahier (10898871), Matthaios Papadimitriou-Olivgeris (9640936), Lauro Damonti (10898874), Oriol Manuel (3445016), Robin Liechti (83112), Lou Götz (5617598), Jonathan Tschopp (9640948), Mathieu Quinodoz (7274789), Peter Vollenweider (93049), Jean-Luc Pagani (9640969), Mauro Oddo (4115593), Olivier Hügli (10898877), Frédéric Lamoth (352803), Véronique Erard (8174250), Cathy Voide (10898880), Mauro Delorenzi (13915), Nathalie Rufer (70403), Fabio Candotti (381384), Carlo Rivolta (121162), Noémie Boillat-Blanco (729621), Pierre-Yves Bochud (205597), the RegCOVID Study Group (10898883) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, COVID-19, SARS-CoV-2, influenza, whole blood transcriptome, RNA-sequencing, immune profiling |
| الوصف: |
The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly rely on dysregulated immunity. Here, we compared transcriptomic profiles of blood cells from 103 patients with different severity levels of COVID-19 with that of 27 healthy and 22 influenza-infected individuals. Data provided a complete overview of SARS-CoV-2-induced immune signature, including a dramatic defect in IFN responses, a reduction of toxicity-related molecules in NK cells, an increased degranulation of neutrophils, a dysregulation of T cells, a dramatic increase in B cell function and immunoglobulin production, as well as an important over-expression of genes involved in metabolism and cell cycle in patients infected with SARS-CoV-2 compared to those infected with influenza viruses. These features also differed according to COVID-19 severity. Overall and specific gene expression patterns across groups can be visualized on an interactive website (https://bix.unil.ch/covidTest/). Collectively, these transcriptomic host responses to SARS-CoV-2 infection are discussed in the context of current studies, thereby improving our understanding of COVID-19 pathogenesis and shaping the severity level of COVID-19. |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/figure/Image_10_Transcriptomic_Signature_Differences_Between_SARS-CoV-2_and_Influenza_Virus_Infected_Patients_png/14705418Test |
| DOI: |
10.3389/fimmu.2021.666163.s002 |
| الإتاحة: |
https://doi.org/10.3389/fimmu.2021.666163.s002Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.624D7770 |
| قاعدة البيانات: |
BASE |
