دورية أكاديمية
YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells
| العنوان: | YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells |
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| المؤلفون: | Wang, Jia, Wu, Xingui, Wei, Chao, Huang, Xin, Ma, Qian, Huang, Xiaona, Faiola, Francesco, Guallar, Diana, Fidalgo, Miguel, Huang, Tingyuan, Peng, Di, Chen, Li, Yu, Haopeng, Li, Xingyu, Sun, Junyi, Liu, Xinyi, Cai, Xiaoxia, Chen, Xiao, Wang, Ling, Ren, Jian, Wang, Jianlong, Ding, Junjun |
| سنة النشر: | 2018 |
| المجموعة: | Research Center for Eco-Environmental Sciences: RCEES OpenIR (Chinese Academy of Sciences) / 中国科学院生态环境研究中心机构知识库 |
| الوصف: | Yin Yang 1 (YY1) regulates early embryogenesis and adult tissue formation. However, the role of YY1 in stem cell regulation remains unclear. YY1 has a Polycomb group (PcG) protein-dependent role in mammalian cells. The PcG-independent functions of YY1 are also reported, although their underlying mechanism is still undefined. This paper reports the role of YY1 and BAF complex in the OCT4-mediated pluripotency network in mouse embryonic stem cells (mESCs). The interaction between YY1 and BAF complex promotes mESC proliferation and pluripotency. Knockdown of Yy1 or Smarca4, the core component of the BAF complex, downregulates pluripotency markers and upregulates several differentiation markers. Moreover, YY1 enriches at both promoter and super-enhancer regions to stimulate transcription. Thus, this study elucidates the role of YY1 in regulating pluripotency through its interaction with OCT4 and the BAF complex and the role of BAF complex in integrating YY1 into the core pluripotency network. |
| نوع الوثيقة: | article in journal/newspaper report |
| اللغة: | unknown |
| العلاقة: | STEM CELL REPORTS; http://ir.rcees.ac.cn/handle/311016/41083Test |
| الإتاحة: | http://ir.rcees.ac.cn/handle/311016/41083Test |
| حقوق: | cn.org.cspace.api.content.CopyrightPolicy@57e00d26 |
| رقم الانضمام: | edsbas.622759FE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |