دورية أكاديمية
Transdermal wires for improved integration in vivo.
| العنوان: | Transdermal wires for improved integration in vivo. |
|---|---|
| المؤلفون: | Kourouklis, Andreas P, Kaemmel, Julius, Wu, Xi, Baños, Miguel, Chanfon, Astrid, De Brot, Simone, Ferrari, Aldo, Cesarovic, Nikola, Falk, Volkmar, Mazza, Edoardo |
| المصدر: | Kourouklis, Andreas P; Kaemmel, Julius; Wu, Xi; Baños, Miguel; Chanfon, Astrid; De Brot, Simone; Ferrari, Aldo; Cesarovic, Nikola; Falk, Volkmar; Mazza, Edoardo (2023). Transdermal wires for improved integration in vivo. Biomaterials advances, 153, p. 213568. Elsevier 10.1016/j.bioadv.2023.213568 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | BORIS (Bern Open Repository and Information System, University of Bern) |
| مصطلحات موضوعية: | 630 Agriculture |
| الوصف: | Alternative engineering approaches have led the design of implants with controlled physical features to minimize adverse effects in biological tissues. Similar efforts have focused on optimizing the design features of percutaneous VAD drivelines with the aim to prevent infection, omitting however a thorough look on the implant-skin interactions that govern local tissue reactions. Here, we utilized an integrated approach for the biophysical modification of transdermal implants and their evaluation by chronic sheep implantation in comparison to the standard of care VAD drivelines. We developed a novel method for the transfer of breath topographical features on thin wires with modular size. We examined the impact of implant's diameter, surface topography, and chemistry on macroscopic, histological, and physical markers of inflammation, fibrosis, and mechanical adhesion. All implants demonstrated infection-free performance. The fibrotic response was enhanced by the increasing diameter of implants but not influenced by their surface properties. The implants of small diameter promoted mild inflammatory responses with improved mechanical adhesion and restricted epidermal downgrowth, in both silicone and polyurethane coated transdermal wires. On the contrary, the VAD drivelines with larger diameter triggered severe inflammatory reactions with frequent epidermal downgrowth. We validated these effects by quantifying the infiltration of macrophages and the level of vascularization in the fibrotic zone, highlighting the critical role of size reduction for the benign integration of transdermal implants with skin. This insight on how the biophysical properties of implants impact local tissue reactions could enable new solutions on the transdermal transmission of power, signal, and mass in a broad range of medical devices. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://boris.unibe.ch/185546Test/ |
| الإتاحة: | https://doi.org/10.1016/j.bioadv.2023.213568Test https://boris.unibe.ch/185546/1/1-s2.0-S2772950823002911-main.pdfTest https://boris.unibe.ch/185546Test/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.61BC8B95 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |