دورية أكاديمية
Serum Metabolomic Profiling Identifies Characterization of Non-Obstructive Azoospermic Men
| العنوان: | Serum Metabolomic Profiling Identifies Characterization of Non-Obstructive Azoospermic Men |
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| المؤلفون: | Zhang, Zhe, Zhang, Yingwei, Liu, Changjie, Zhao, Mingming, Yang, Yuzhuo, Wu, Han, Zhang, Hongliang, Lin, Haocheng, Zheng, Lemin, Jiang, Hui |
| المساهمون: | Jiang, H (reprint author), Peking Univ, Dept Urol, Hosp 3, Beijing 100191, Peoples R China., Zheng, LM (reprint author), Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Inst Syst Biomed,Sch Basic Med Sci, Beijing 100191, Peoples R China., Zheng, LM (reprint author), Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100191, Peoples R China., Peking Univ, Dept Urol, Hosp 3, Beijing 100191, Peoples R China., Gen Hosp Jinan Mil, Dept Nephrol, Jinan 250000, Peoples R China., Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Inst Syst Biomed,Sch Basic Med Sci, Beijing 100191, Peoples R China., Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100191, Peoples R China., Peking Univ Third Hosp, Dept Human Sperm Bank, Hosp 3, Beijing 100191, Peoples R China. |
| المصدر: | SCI |
| بيانات النشر: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| سنة النشر: | 2017 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | non-obstructive azoospermia, metabolomic, serum, HPLC-MS, MS, biomarkers, MALE-INFERTILITY, METHOXYACETIC ACID, OXIDATIVE STRESS, SEMINAL PLASMA, SPERMATOGENESIS, SPERMATOZOA, CELLS, APOPTOSIS, SULFATE, MALES |
| الوصف: | Male infertility is considered a common health problem, and non-obstructive azoospermia with unclear pathogenesis is one of the most challenging tasks for clinicians. The objective of this study was to investigate the differential serum metabolic pattern in non-obstructive azoospermic men and to determine potential biomarkers related to spermatogenic dysfunction. Serum samples from patients with non-obstructive azoospermia (n = 22) and healthy controls (n = 31) were examined using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Serum metabolomic profiling could differentiate non-obstructive azoospermic patients from healthy control subjects. A total of 24 metabolites were screened and identified as potential markers, many of which are involved in energy production, oxidative stress and cell apoptosis in spermatogenesis. Moreover, the results showed that various metabolic pathways, including d-glutamine and d-glutamate metabolism, taurine and hypotaurine metabolism, pyruvate metabolism, the citrate cycle and alanine, aspartate and glutamate metabolism, were disrupted in patients with non-obstructive azoospermia. Our results indicated that the serum metabolic disorders may contribute to the etiology of non-obstructive azoospermia. This study suggested that serum metabolomics could identify unique metabolic patterns of non-obstructive azoospermia and provide novel insights into the pathogenesis underlying male infertility. ; Peking University 985 Clinical Hospital Cooperation Program; National Science Foundation of China [81322005, 81370235] ; SCI(E) ; ARTICLE ; 2 ; 18 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 |
| العلاقة: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2017,18(2).; 1909857; http://hdl.handle.net/20.500.11897/475351Test; WOS:000395457700008 |
| DOI: | 10.3390/ijms18020238 |
| الإتاحة: | https://doi.org/20.500.11897/475351Test https://doi.org/10.3390/ijms18020238Test https://hdl.handle.net/20.500.11897/475351Test |
| رقم الانضمام: | edsbas.61B91643 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms18020238 |