التفاصيل البيبلوغرافية
| العنوان: |
Syt1 M3 bladder strips are less sensitive to BoNT/B than WT bladder strips. |
| المؤلفون: |
Hatim Thaker (7928519), Jie Zhang (64655), Shin-Ichiro Miyashita (6184568), Vivian Cristofaro (586878), SunHyun Park (11576924), Ali Hashemi Gheinani (11619876), Maryrose P. Sullivan (11576930), Rosalyn M. Adam (11576933), Min Dong (123378) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Pharmacology, Biotechnology, Evolutionary Biology, Immunology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, wild type mice, target neurons determines, skeletal neuromuscular junctions, potent toxins known, dominant toxin receptor, bonts &# 8217, analyzing bont action, dominant receptor, injecting toxins, wide range, two sets, therapeutic efficacy, overactive bladder, leg muscle, findings establish |
| الوصف: |
A. Contractile responses to electrical field stimulation of WT and KI mice, in the setting of high dose (1 nM) of BoNT/B. WT and Syt2 M3 bladder strips have decreased contractile capability, while Syt1 M3 bladders are largely resistant to the effect of BoNT/B. Only under long duration (300 mins) of 1 nM BoNT/B do Syt1 M3 bladders begin to become slightly paralyzed. B. Carbachol treatment validates that bladder muscle viability and contractility remain unchanged after incubation with high dose BoNT/B. C. Survival curve for direct bladder wall injection of BoNT/B revealed the highest tolerable dose injected into the bladder is 3.25 pg. Systemic toxicity and death resulted from 4.25 pg bladder injection. WT 1 nM BoNT/B (n = 2); Syt1 M3 1 nM BoNT/B (n = 5); Syt2 M3 1 nM BoNT/B (n = 5). (TIF) |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/figure/Syt1_sup_M3_sup_bladder_strips_are_less_sensitive_to_BoNT_B_than_WT_bladder_strips_/16827695Test |
| DOI: |
10.1371/journal.ppat.1009994.s004 |
| الإتاحة: |
https://doi.org/10.1371/journal.ppat.1009994.s004Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.61A16DBC |
| قاعدة البيانات: |
BASE |
