صورة
mDia formins are required for cell recovery in 5-FU-induced myeloid suppression.
| العنوان: | mDia formins are required for cell recovery in 5-FU-induced myeloid suppression. |
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| المؤلفون: | Zhaofeng Li, Meng Su, Xinshu Xie, Pan Wang, Honghao Bi, Ermin Li, Kehan Ren, Lili Dong, Zhiyi Lv, Xuezhen Ma, Yijie Liu, Baobing Zhao, Yuanliang Peng, Jing Liu, Lu Liu, Jing Yang, Peng Ji, Yang Mei |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Hematology, Computational Biology, Biological Sciences not elsewhere classified, serum response factor, linear actin nucleation, involved transcriptional signaling, filamentous actin network, mdia2 regulates enucleation, mdia2 dad domains, mdia formins interplay, mdia2 form hetero, mdia1 deficiency leads, mdia hetero, significant mortality, severe anemia, serial plating, rodent functions, regulate hematopoiesis, progenitor cells, potential roles, polymerization activities, newborn mice, myeloid ablation, mouse model |
| الوصف: | (A) The numbers of HSPCs and committed progenitors from purified lineage-negative cells were analyzed and quantified by flow cytometer analysis by day 7 after 5-FU treatment. (B) Survival percentage of lineage-negative cells from A assayed by Annexin V staining. (C) Complete blood cell counts of wild-type or mDia1 KO mice were determined by day 7 after the first injection of 5-FU. (D) Kaplan-Meier survival analysis of indicated mice challenged with serial 5-FU injection. Error bars represent the SEM of the mean. * p <0.05, ** p <0.01, *** p <0.001, **** p <0.0001. Two-tailed unpaired student’s t-test was used to generate the p values. (TIFF) |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/figure/mDia_formins_are_required_for_cell_recovery_in_5-FU-induced_myeloid_suppression_/24919450Test |
| DOI: | 10.1371/journal.pgen.1011084.s005 |
| الإتاحة: | https://doi.org/10.1371/journal.pgen.1011084.s005Test https://figshare.com/articles/figure/mDia_formins_are_required_for_cell_recovery_in_5-FU-induced_myeloid_suppression_/24919450Test |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.6193EE9F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pgen.1011084.s005 |
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