دورية أكاديمية
Tapinanthus bangwensis (Mistletoe) reduces some increased lipid profile parameters caused by alloxan-induced diabetes in Wistar Rats
| العنوان: | Tapinanthus bangwensis (Mistletoe) reduces some increased lipid profile parameters caused by alloxan-induced diabetes in Wistar Rats |
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| المؤلفون: | Stephen I. Omeodu, Felicia N. Okwakpam |
| المصدر: | International Journal of Recent Research in Interdisciplinary Sciences (IJRRIS) 10(2) 11-15 |
| سنة النشر: | 2023 |
| المجموعة: | Zenodo |
| مصطلحات موضوعية: | Tapinanthus bangwensis, Mistletoe, serum lipid metabolites, elevated parameters, lipid profile, Alloxan, diabetes, Wistar rats, Paper Download Link (Source) |
| الوصف: | This study investigated the effect of aqueous extract of Tapinanthus bangwensis (T. bangwensis) on some lipid profiles in alloxan-induced diabetic Wistar rats. The effects of this plant extract were monitored on the serum concentrations of triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C) and cholesterol (CHOL). Sixty-six albino rats were used for the study arranged into eleven groups of six rats each. Two groups (12 rats) were used for a pilot study. Nine other groups (54 rats) were used for the experiment labeled groups 1-9. Group 1 constitutes the normal control which received only feed and water, group 2 received 50mg/kg citrate buffer. Alloxan was dissolved in 0.1M citrate buffer solution, pH 4.5. Group 3 received 50mg/kg alloxan dissolved in citrate buffer in a 1:1 ratio intraperitoneally. Groups 4-6 were treated with 50mg/kg citrate buffer with 5%, 7%, and 10% aqueous extract of T. bangwensis respectively. Groups 7-9 received 50mg/kg alloxan dissolved in citrate buffer in a 1:1 ratio intraperitoneally with 5%, 7%, and 10% aqueous extract of T. bangwensis respectively. Blood samples were collected into appropriately labeled sampled bottles and analyzed. Results of the blood analysis showed that alloxan caused diabetes mellitus in the experimental animals. Lipid profile parameters such as triglyceride (TG) (0.820±0.01), high-density lipoprotein cholesterol (HDL-CHOL) (0.480±0.00), and cholesterol (CHOL) (2.100±0.06) of the control animals were found to be within the normal range. These parameters significantly increased in the animals induced with diabetes but not treated. Treatment with the plant extract sparingly reduced the raised serum triglycerides in a dose-dependent manner. This study was able to establish the diabetogenicity of alloxan as seen in lipids, concentrations are elevated and treatment with Tapinanthus bangwensis reduced the raised serum triglycerides. Keywords: Tapinanthus bangwensis, Mistletoe, serum lipid metabolites, elevated parameters, lipid profile, Alloxan, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2350-1049 |
| العلاقة: | https://www.paperpublications.org/upload/book/Tapinanthus%20bangwensis%20Test(Mistletoe)-20042023-1.pdf; https://zenodo.org/record/7849089Test; https://doi.org/10.5281/zenodo.7849089Test; oai:zenodo.org:7849089 |
| DOI: | 10.5281/zenodo.7849089 |
| الإتاحة: | https://doi.org/10.5281/zenodo.7849089Test https://doi.org/10.5281/zenodo.7849088Test https://zenodo.org/record/7849089Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by/4.0/legalcodeTest |
| رقم الانضمام: | edsbas.60CD6710 |
| قاعدة البيانات: | BASE |
| تدمد: | 23501049 |
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| DOI: | 10.5281/zenodo.7849089 |