دورية أكاديمية
Mesoporous MOFs with ROS scavenging capacity for the alleviation of inflammation through inhibiting stimulator of interferon genes to promote diabetic wound healing ...
| العنوان: | Mesoporous MOFs with ROS scavenging capacity for the alleviation of inflammation through inhibiting stimulator of interferon genes to promote diabetic wound healing ... |
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| المؤلفون: | Li, Fupeng, Mao, Zhiyuan, Du, Yun, Cui, Yuehan, Yang, Shengbing, Huang, Kai, Yang, Jian, Li, Zhuoyuan, Liu, Yihao, Gu, Jinlou, Wang, Danru, Wang, Chen |
| بيانات النشر: | figshare |
| سنة النشر: | 2024 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: | Biochemistry, Space Science, Medicine, Microbiology, FOS Biological sciences, Cell Biology, Molecular Biology, Chemical Sciences not elsewhere classified, Immunology, FOS Clinical medicine, Biological Sciences not elsewhere classified, Cancer, Infectious Diseases, FOS Health sciences |
| الوصف: | Excessive production of reactive oxygen species (ROS) and inflammation are the key problems that impede diabetic wound healing. In particular, dressings with ROS scavenging capacity play a crucial role in the process of chronic wound healing. Herein, Zr-based large-pore mesoporous metal–organic frameworks (mesoMOFs) were successfully developed for the construction of spatially organized cascade bioreactors. Natural superoxide dismutase (SOD) and an artificial enzyme were spatially organized in these hierarchical mesoMOFs, forming a cascade antioxidant defense system, and presenting efficient intracellular and extracellular ROS scavenging performance. In vivo experiments demonstrated that the SOD@HMUiO-MnTCPP nanoparticles (S@M@H NPs) significantly accelerated diabetic wound healing. Transcriptomic and western blot results further indicated that the nanocomposite could inhibit fibroblast senescence and ferroptosis as well as the stimulator of interferon genes (STING) signaling pathway activation in ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://dx.doi.org/10.6084/m9.figshare.c.7230270Test |
| DOI: | 10.6084/m9.figshare.c.7230270.v1 |
| الإتاحة: | https://doi.org/10.6084/m9.figshare.c.7230270.v110.6084/m9.figshare.c.7230270Test https://springernature.figshare.com/collections/Mesoporous_MOFs_with_ROS_scavenging_capacity_for_the_alleviation_of_inflammation_through_inhibiting_stimulator_of_interferon_genes_to_promote_diabetic_wound_healing/7230270/1Test |
| حقوق: | Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcodeTest ; cc-by-4.0 |
| رقم الانضمام: | edsbas.60CB742D |
| قاعدة البيانات: | BASE |
| DOI: | 10.6084/m9.figshare.c.7230270.v1 |
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