دورية أكاديمية
Psychological outcomes of COVID-19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress
| العنوان: | Psychological outcomes of COVID-19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress |
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| المؤلفون: | YILDIZ, YEŞİM, ŞENOL, ESİN, CANDANSAYAR, SELÇUK, Deveci-Bulut, Tuba S., YAZ AYDIN, GİZEM, GÜLBAHAR, ÖZLEM, Yay-Pence, Aysegul, BÜYÜKKÖRÜK, MERVE, KÜÇÜKKARAPINAR, MELİKE |
| سنة النشر: | 2022 |
| الوصف: | Coronavirus disease 2019 (COVID-19) has resulted in long-term psychiatric symptoms because of the immunologic response to the virus itself as well as fundamental life changes related to the pandemic. This immune response leads to altered tryptophan (TRP)-kynurenine (KYN) pathway (TKP) metabolism, which plays an essential role in the pathophysiology of mental illnesses. We aimed to define TKP changes as a potential underlying mechanism of psychiatric disorders in post-COVID-19 patients. We measured plasma levels of several TKP markers, including KYN, TRP, kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), and quinolinic acid (QUIN), as well as the TRP/KYN, KYNA/3-HK, and KYNA/QUIN ratios, in 90 post-COVID-19 patients (on the first day of hospitalization) and 59 healthy controls (on the first admission to the Check-Up Center). An online questionnaire that included the Depression, Anxiety and Stress Scale-21 (DASS-21) was used 6 months after the initial assessment in both groups. A total of 32.2% of participants with COVID-19 showed depressive symptoms, 21.1% exhibited anxiety, and 33.3% had signs of stress at follow-up, while 6.6% of healthy controls exhibited depressive and anxiety symptoms and 18.6% had signs of stress. TRP and 3-HK were negative predictors of anxiety and stress, but KYN positively predicted anxiety and stress. Moreover, TRP negatively predicted depression, while KYNA/3-HK was a negative predictor of anxiety. The correlation between depression, anxiety, and stress and TKP activation in COVID-19 could provide prospective biomarkers, especially the reduction in TRP and 3HK levels and the increase in KYN. Our results suggest that the alteration of TKP is not only a potential biomarker of viral infection-related long-term psychiatric disorders but also that the therapy targets future viral infections related to depression and anxiety. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | a5f9223e-e711-4570-b2f4-e620f84647a7; https://avesis.gazi.edu.tr/publication/details/a5f9223e-e711-4570-b2f4-e620f84647a7/oaiTest |
| DOI: | 10.1007/s00702-022-02525-1 |
| الإتاحة: | https://doi.org/10.1007/s00702-022-02525-1Test https://avesis.gazi.edu.tr/publication/details/a5f9223e-e711-4570-b2f4-e620f84647a7/oaiTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.604A05CA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00702-022-02525-1 |
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