دورية أكاديمية
Incidence of paradoxical reactions in patients treated with tocilizumab for rheumatoid arthritis: Data from the French registry REGATE
| العنوان: | Incidence of paradoxical reactions in patients treated with tocilizumab for rheumatoid arthritis: Data from the French registry REGATE |
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| المؤلفون: | Terreaux, William, Masson, Claire, Eschard, Jean-Paul, Bardin, Thomas, Constantin, Arnaud, Le Dantec, Loïc, Marcelli, Christian, Perdriger, Aleth, Scotto Di Fazano, Claire, Wendling, Daniel, Sibilia, Jean, Morel, Jacques, Salmon, Jean |
| المساهمون: | Hôpital universitaire Robert Debré Reims (CHU Reims), Service de Rhumatologie CHU Lariboisière, Hôpital Lariboisière-Fernand-Widal APHP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), School of Informatics Edimbourg, University of Edinburgh (Edin.), Hôpital de Riaumont Lievin, Service de Rhumatologie CHU Caen, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Mobilités : Vieillissement, Pathologie, Santé (COMETE), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Centre Hospitalier Saint Jean de Perpignan, Service de Rhumatologie, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Immuno-Rhumatologie Moléculaire (IRM), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Rhumatologie Montpellier, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Hôpital Lapeyronie, Laboratoire Traitement et Communication de l'Information (LTCI), Télécom ParisTech-Institut Mines-Télécom Paris (IMT)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 1297-319X ; Joint Bone Spine ; https://normandie-univ.hal.science/hal-02190639Test ; Joint Bone Spine, 2018, 85 (1), pp.53-57. ⟨10.1016/j.jbspin.2017.01.002⟩. |
| بيانات النشر: | HAL CCSD Elsevier Masson |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Tocilizumab, Paradoxical reactions, Rheumatoid arthritis, Vasculitis, Lupus, Uveitis, [SDV]Life Sciences [q-bio], [SCCO.NEUR]Cognitive science/Neuroscience, [SHS.PSY]Humanities and Social Sciences/Psychology |
| الوصف: | International audience ; ObjectivesAssess the frequency of paradoxical reactions encountered in daily practice under tocilizumab, using the REGATE (Registry-RoActemra) registry. The secondary objectives were to determine the type of paradoxical reaction and the consequences of these reactions.MethodsThe REGATE registry is an independent prospective registry, promoted by the French Society of Rheumatology, consisting of patients treated with tocilizumab for rheumatoid arthritis. The paradoxical reaction was retained if it was a paradoxical precipitation of a condition for which tocilizumab was indicated, if tocilizumab was being used for an alternative indication, and if it appeared after at least one tocilizumab infusion.ResultsAmong the 1491 patients included with at least one follow-up visit (3429 patient-years), a paradoxical reaction occurred in 9 patients (0.60% of patients; 2.62/1000 patient-years). These were 7 de novo pathologies (3 vasculitis, 3 uveitis, 1 lupus) and 2 exacerbations of pre-existing conditions (1 vasculitis, 1 lupus). Permanent discontinuation of tocilizumab was chosen for 5 patients.ConclusionsIn the REGATE registry, the occurrence of paradoxical reactions in patients treated with tocilizumab was rare. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-02190639; https://normandie-univ.hal.science/hal-02190639Test |
| DOI: | 10.1016/j.jbspin.2017.01.002 |
| الإتاحة: | https://doi.org/10.1016/j.jbspin.2017.01.002Test https://normandie-univ.hal.science/hal-02190639Test |
| رقم الانضمام: | edsbas.60151645 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jbspin.2017.01.002 |
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