التفاصيل البيبلوغرافية
| العنوان: |
Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project |
| المؤلفون: |
Sajatovic, Martha, Rej, Soham, Almeida, Osvaldo P., Altinbas, Kursat, Balanzá‐Martínez, Vicent, Barbosa, Izabela G., Beunders, Alexandra J. M., Blumberg, Hilary P., Briggs, Farren B. S., Dols, Annemiek, Forester, Brent P., Forlenza, Orestes V., Gildengers, Ariel G., Jimenez, Esther, Klaus, Federica, Lafer, Beny, Mulsant, Benoit, Mwangi, Benson, Nunes, Paula Villela, Olagunju, Andrew T., Oluwaniyi, Stephen, Orhan, Melis, Patrick, Regan E., Radua, Joaquim, Rajji, Tarek, Sarna, Kaylee, Schouws, Sigfried, Simhandl, Christian, Sekhon, Harmehr, Soares, Jair C., Sutherland, Ashley N., Teixeira, Antonio L., Tsai, Shangying, Vidal‐Rubio, Sonia, Vieta, Eduard, Yala, Joy, Eyler, Lisa T. |
| المساهمون: |
National Institutes of Health, National Center for Advancing Translational Sciences, International Society for Bipolar Disorders, Clinical and Translational Science Collaborative of Cleveland, School of Medicine, Case Western Reserve University |
| المصدر: |
International Journal of Geriatric Psychiatry ; volume 39, issue 3 ; ISSN 0885-6230 1099-1166 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Objectives The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE‐BD) project pools archival datasets on older age bipolar disorder (OABD). An initial Wave 1 (W1; n = 1369) analysis found both manic and depressive symptoms reduced among older patients. To replicate this finding, we gathered an independent Wave 2 (W2; n = 1232, mean ± standard deviation age 47.2 ± 13.5, 65% women, 49% aged over 50) dataset. Design/Methods Using mixed models with random effects for cohort, we examined associations between BD symptoms, somatic burden and age and the contribution of these to functioning in W2 and the combined W1 + W2 sample (n = 2601). Results Compared to W1, the W2 sample was younger ( p < 0.001), less educated ( p < 0.001), more symptomatic ( p < 0.001), lower functioning ( p < 0.001) and had fewer somatic conditions ( p < 0.001). In the full W2, older individuals had reduced manic symptom severity, but age was not associated with depression severity. Age was not associated with functioning in W2. More severe BD symptoms (mania p ≤ 0.001, depression p ≤ 0.001) were associated with worse functioning. Older age was significantly associated with higher somatic burden in the W2 and the W1 + W2 samples, but this burden was not associated with poorer functioning. Conclusions In a large, independent sample, older age was associated with less severe mania and more somatic burden (consistent with previous findings), but there was no association of depression with age (different from previous findings). Similar to previous findings, worse BD symptom severity was associated with worse functioning, emphasizing the need for symptom relief in OABD to promote better functioning. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/gps.6057 |
| الإتاحة: |
https://doi.org/10.1002/gps.6057Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.600D9EEC |
| قاعدة البيانات: |
BASE |
