دورية أكاديمية
Impact of admission hyperglycemia on short and long-term prognosis in acute myocardial infarction: MINOCA versus MIOCA
| العنوان: | Impact of admission hyperglycemia on short and long-term prognosis in acute myocardial infarction: MINOCA versus MIOCA |
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| المؤلفون: | Paolisso P., Foa A., Bergamaschi L., Angeli F., Fabrizio M., Donati F., Toniolo S., Chiti C., Rinaldi A., Stefanizzi A., Armillotta M., Sansonetti A., Magnani I., Iannopollo G., Rucci P., Casella G., Galie N., Pizzi C. |
| المساهمون: | Paolisso P., Foa A., Bergamaschi L., Angeli F., Fabrizio M., Donati F., Toniolo S., Chiti C., Rinaldi A., Stefanizzi A., Armillotta M., Sansonetti A., Magnani I., Iannopollo G., Rucci P., Casella G., Galie N., Pizzi C. |
| سنة النشر: | 2021 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Acute myocardial infarction, Long-term prognosi, MINOCA, MIOCA, Short-term prognosi, Stress-hyperglycemia |
| الوصف: | Background: The prognostic role of hyperglycemia in patients with myocardial infarction and obstructive coronary arteries (MIOCA) is acknowledged, while data on non-obstructive coronary arteries (MINOCA) are still lacking. Recently, we demonstrated that admission stress-hyperglycemia (aHGL) was associated with a larger infarct size and inflammatory response in MIOCA, while no differences were observed in MINOCA. We aim to investigate the impact of aHGL on short and long-term outcomes in MIOCA and MINOCA patients. Methods: Multicenter, population-based, cohort study of the prospective registry, designed to evaluate the prognostic information of patients admitted with acute myocardial infarction to S. Orsola-Malpighi and Maggiore Hospitals of Bologna metropolitan area. Among 2704 patients enrolled from 2016 to 2020, 2431 patients were classified according to the presence of aHGL (defined as admission glucose level ≥ 140mg/dL) and AMI phenotype (MIOCA/MINOCA): no-aHGL (n = 1321), aHGL (n = 877) in MIOCA and no-aHGL (n = 195), aHGL (n = 38) in MINOCA. Short-term outcomes included in-hospital death and arrhythmias. Long-term outcomes were all-cause and cardiovascular mortality. Results: aHGL was associated with a higher in-hospital arrhythmic burden in MINOCA and MIOCA, with increased in-hospital mortality only in MIOCA. After adjusting for age, gender, hypertension, Killip class and AMI phenotypes, aHGL predicted higher in-hospital mortality in non-diabetic (HR = 4.2; 95% CI 1.9–9.5, p = 0.001) and diabetic patients (HR = 3.5, 95% CI 1.5–8.2, p = 0.003). During long-term follow-up, aHGL was associated with 2-fold increased mortality in MIOCA and a 4-fold increase in MINOCA (p = 0.032 and p = 0.016). Kaplan Meier 3-year survival of non-hyperglycemic patients was greater than in aHGL patients for both groups. No differences in survival were found between hyperglycemic MIOCA and MINOCA patients. After adjusting for age, gender, hypertension, smoking, LVEF, STEMI/NSTEMI and AMI phenotypes (MIOCA/MINOCA), aHGL predicted ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34560876; info:eu-repo/semantics/altIdentifier/wos/WOS:000698950100001; volume:20; issue:1; firstpage:192; lastpage:201; numberofpages:10; journal:CARDIOVASCULAR DIABETOLOGY; http://hdl.handle.net/11585/835250Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85115730733; https://cardiab.biomedcentral.com/articles/10.1186/s12933-021-01384-6Test |
| DOI: | 10.1186/s12933-021-01384-6 |
| الإتاحة: | https://doi.org/10.1186/s12933-021-01384-6Test http://hdl.handle.net/11585/835250Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5FD98408 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12933-021-01384-6 |
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