دورية أكاديمية
Increase in relative deposition of fine particles in the rat lung periphery in the absence of gravity
| العنوان: | Increase in relative deposition of fine particles in the rat lung periphery in the absence of gravity |
|---|---|
| المؤلفون: | Darquenne, Chantal, Borja, Maria G., Oakes, Jessica M., Breen, Ellen C., Olfert, Mark, Scadeng, Miriam, Prisk, G. Kim |
| المساهمون: | Department of Medicine Univ California San Diego (MED - UC San Diego), School of Medicine Univ California San Diego (UC San Diego), University of California San Diego (UC San Diego), University of California (UC)-University of California (UC)-University of California San Diego (UC San Diego), University of California (UC)-University of California (UC), Department of Mechanical and Aerospace Engineering Univ California San Diego (MAE - UC San Diego), Numerical simulation of biological flows (REO), Laboratoire Jacques-Louis Lions (LJLL), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Inria Paris-Rocquencourt, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Department of Radiology Univ California San Diego (UC San Diego) |
| المصدر: | ISSN: 8750-7587. |
| بيانات النشر: | HAL CCSD American Physiological Society |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | MRI, aerosol, lunar dust, microgravity, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] |
| الوصف: | International audience ; While it is well recognized that pulmonary deposition of inhaled particles is lowered in microgravity (μG) compared with gravity on the ground (1G), the absence of sedimentation causes fine particles to penetrate deeper in the lung in μG. Using quantitative magnetic resonance imaging (MRI), we determined the effect of gravity on peripheral deposition (DEPperipheral) of fine particles. Aerosolized 0.95-μm-diameter ferric oxide particles were delivered to spontaneously breathing rats placed in plethysmographic chambers both in μG aboard the NASA Microgravity Research Aircraft and at 1G. Following exposure, lungs were perfusion fixed, fluid filled, and imaged in a 3T MR scanner. The MR signal decay rate, R2*, was measured in each voxel of the left lung from which particle deposition (DEP) was determined based on a calibration curve. Regional deposition was assessed by comparing DEP between the outer (DEPperipheral) and inner (DEPcentral) areas on each slice, and expressed as the central-to-peripheral ratio. Total lung deposition tended to be lower in μG compared with 1G (1.01 ± 0.52 vs. 1.43 ± 0.52 μg/ml, P = 0.1). In μG, DEPperipheral was larger than DEPcentral (P < 0.03), while, in 1G, DEPperipheral was not significantly different from DEPcentral. Finally, central-to-peripheral ratio was significantly less in μG than in 1G (P ≤ 0.05). These data show a larger fraction of fine particles depositing peripherally in μG than in 1G, likely beyond the large- and medium-sized airways. Although not measured, the difference in the spatial distribution of deposited particles between μG and 1G could also affect particle retention rates, with an increase in retention for particles deposited more peripherally. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-01100097; https://inria.hal.science/hal-01100097Test |
| الإتاحة: | https://inria.hal.science/hal-01100097Test |
| رقم الانضمام: | edsbas.5FC8E941 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |