دورية أكاديمية
The Mechanism of Dendrobium officinale as a Treatment for Hyperlipidemia Based on Network Pharmacology and Experimental Validation
| العنوان: | The Mechanism of Dendrobium officinale as a Treatment for Hyperlipidemia Based on Network Pharmacology and Experimental Validation |
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| المؤلفون: | Lin-Zi Li, Hui-Ying Wang, Jia-Hui Huang, Kun Liu, Xiao-Jie Feng, Xi-Ming Wang, Li-Jie Zhu, Xing-Lishang He, Xiang Zheng, Hai-Long Li, Ying-Jie Dong, Bo Li, Han-Song Wu, Ning-Hua Jiang, Gui-Yuan Lv, Su-Hong Chen |
| المصدر: | Evidence-Based Complementary and Alternative Medicine, Vol 2022 (2022) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Other systems of medicine, RZ201-999 |
| الوصف: | Aim and Objective. Hyperlipidemia is a public health matter of global scale, contributing to a wide range of diseases that can result in severe complications and significant annual mortality. Dendrobium officinale (DO) is an edible plant with a long medicinal history in China. Our previous studies revealed that DO may have therapeutic benefits in lipid disorders. However, the mechanism of its active compounds is still unclear. This research aimed at uncovering the hidden anti-hyperlipidemia mechanisms of DO through network pharmacology and experimental validation. Materials and Methods. The active compounds in DO, their targets, and targets associated with hyperlipidemia were screened across various databases, and the hidden targets of DO in treating hyperlipidemia were forecast. The compound-target (C-T), protein-protein interaction (PPI), and compound-target-pathway (C-T-P) networks of DO were set up with Cytoscape software. The hub genes and core clusters of DO predicted to be active against hyperlipidemia were calculated by Cytoscape. The DAVID database was adopted for Gene Ontology (GO) analysis and KEGG pathway enrichment analysis. Next, we used the high-sucrose-fat diet and alcohol (HFDA)-induced hyperlipidemia rats to evaluate the hypolipidemic effect of DO. Results. In this study, we obtained 264 compounds from DO, revealed 11 bioactive compounds, and predicted 89 potential targets of DO. The network analysis uncovered that naringenin, isorhamnetin, and taxifolin might be the compounds in DO that are mainly in charge of its roles in hyperlipidemia and might play a role by modulating the targets (including PPARG, ADIPOQ, AKT1, TNF, and APOB). The pathway analysis showed that DO might affect diverse signaling pathways related to the pathogenesis of hyperlipidemia, including PPAR signaling pathway, insulin resistance, AMPK signaling pathway, and non-alcoholic fatty liver disease simultaneously. Meanwhile, in the HFDA-induced hyperlipidemia rat model, DO could significantly decrease the level of TC, TG, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1741-4288 |
| العلاقة: | http://dx.doi.org/10.1155/2022/5821829Test; https://doaj.org/toc/1741-4288Test; https://doaj.org/article/628d26846727415187026dadd17818f8Test |
| DOI: | 10.1155/2022/5821829 |
| الإتاحة: | https://doi.org/10.1155/2022/5821829Test https://doaj.org/article/628d26846727415187026dadd17818f8Test |
| رقم الانضمام: | edsbas.5F912540 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17414288 |
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| DOI: | 10.1155/2022/5821829 |