دورية أكاديمية
Comparison of clinical features between patients with anti-synthetase syndrome and dermatomyositis : results from the MYONET registry
| العنوان: | Comparison of clinical features between patients with anti-synthetase syndrome and dermatomyositis : results from the MYONET registry |
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| المؤلفون: | Hum, Ryan Malcolm, Lilleker, James B, Lamb, Janine A, Oldroyd, Alexander G S, Wang, Guochun, Wedderburn, Lucy R, Diederichsen, Louise P, Schmidt, Jens, Danieli, Maria Giovanna, Oakley, Paula, Griger, Zoltan, Nguyen Thi Phuong, Thuy, Kodishala, Chanakya, Vazquez-Del Mercado, Monica, Andersson, Helena, De Paepe, Boel, De Bleecker, Jan, Maurer, Britta, McCann, Liza, Pipitone, Nicolo, McHugh, Neil, New, Robert Paul, Ollier, William E, Krogh, Niels Steen, Vencovsky, Jiri, Lundberg, Ingrid E, Chinoy, Hector, D’Hose, Sophie, Lu, Xin, Tian, Xiaolan, Mann, Heřman, Kryštůfková, Olga, Pleštilová, Lenka, Klein, Martin, Barochová, Tereza, Kubínová, Kateřina, Gelardi, Chiara, Paladini, Alberto, Piga, Mario Andrea, Jara, Luis J, Saavedra, Miguel A, Cruz-Reyes, Claudia V, Vera-Lastra, Olga, Andrade-Ortega, Lilia, Medrano-Ramírez, Gabriel, Satoh, Minoru, Salazar-Páramo, Mario, Chavarría-Ávila, Efrain, Aguilar-Vazquez, Andrea, Anda, Jesus-Aureliano Robles-de, Petri, Marcelo H, Molberg, Øyvind, Dastmalchi, Maryam, Notarnicola, Antonella, Gheorghe, Karina, Rönnelid, Johan, Liden, Maria, Hanna, Balsam, Jalal, Awat, Hellström, Helena, Martineus, Jehns Christian, Lan, Nguyen Thi Ngoc, Padyukov, Leonid, New, Paul, Platt, Hazel, Rothwell, Simon, Ahmed, Yasmeen, Armstrong, Raymond, Bernstein, Robert, Black, Carol, Bowman, Simon, Bruce, Ian, Butler, Robin, Carty, John, Chattopadhyay, Chandra, Chelliah, Easwaradhas, Clarke, Fiona, Dawes, Peter, Denton, Christopher, Devlin, Joseph, Edwards, Christopher, Emery, Paul, Fordham, John, Fraser, Alexander, Gaston, Hill, Gordon, Patrick, Griffiths, Bridget, Gunawardena, Harsha, Hall, Frances, Hanna, Michael, Harrison, Beverley, Hay, Elaine, Hilton-Jones, David, Horden, Lesley, Isaacs, John, Isenberg, David, Jones, Adrian, Kamath, Sanjeet, Kennedy, Thomas, Kitas, George, Klimiuk, Peter, Knights, Sally, Lambert, John, Lanyon, Peter, Laxminarayan, Ramasharan, Lecky, Bryan, Luqmani, Raashid, Machado, Pedro, Marks, Jeffrey, Martin, Michael, McGonagle, Dennis, McKenna, Francis, McLaren, John, McMahon, Michael, McRorie, Euan, Merry, Peter, Miles, Sarah, Miller, James, Nicholls, Anne, Nixon, Jennifer, Ong, Voon, Over, Katherine, Packham, John, Plant, Michael, Pountain, Gillian, Pullar, Thomas, Roberts, Mark, Sanders, Paul, Scott, David, Shadforth, Michael, Sheeran, Thomas, Srinivasan, Arul, Swinson, David, Teh, Lee-Suan, Webley, Michael, Williams, Brian, Winer, Jonathan, MYONET Registry, missing |
| المصدر: | RHEUMATOLOGY ; ISSN: 1462-0324 ; ISSN: 1462-0332 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2024 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences, Pharmacology (medical), Rheumatology, Extramuscular, MYONET, Epidemiology, Malignancy, Skin, Rashes, Cutaneous, Dermatomyositis, Anti-synthetase syndrome |
| الوصف: | Objectives: To compare clinical characteristics, including the frequency of cutaneous, extramuscular manifestations and malignancy, between adults with anti-synthetase syndrome (ASyS) and DM. Methods: Using data regarding adults from the MYONET registry, a cohort of DM patients with anti-Mi2/-TIF1 gamma/-NXP2/-SAE/-MDA5 autoantibodies, and a cohort of ASyS patients with anti-tRNA synthetase autoantibodies (anti-Jo1/-PL7/-PL12/-OJ/-EJ/-Zo/-KS) were identified. Patients with DM sine dermatitis or with discordant dual autoantibody specificities were excluded. Sub-cohorts of patients with ASyS with or without skin involvement were defined based on presence of DM-type rashes (heliotrope rash, Gottron's papules/sign, violaceous rash, shawl sign, V-sign, erythroderma, and/or periorbital rash). Results: In total 1054 patients were included (DM, n = 405; ASyS, n = 649). In the ASyS cohort, 31% (n = 203) had DM-type skin involvement (ASyS-DMskin). A higher frequency of extramuscular manifestations, including Mechanic's hands, Raynaud's phenomenon, arthritis, interstitial lung disease and cardiac involvement differentiated ASyS-DMskin from DM (all P < 0.001), whereas higher frequency of any of four DM-type rashes-heliotrope rash (n = 248, 61% vs n = 90, 44%), violaceous rash (n = 166, 41% vs n = 57, 9%), V-sign (n = 124, 31% vs n = 28, 4%), and shawl sign (n = 133, 33% vs n = 18, 3%)-differentiated DM from ASyS-DMskin (all P < 0.005). Cancer-associated myositis (CAM) was more frequent in DM (n = 67, 17%) compared with ASyS (n = 21, 3%) and ASyS-DMskin (n = 7, 3%) cohorts (both P < 0.001). Conclusion: DM-type rashes are frequent in patients with ASyS; however, distinct clinical manifestations differentiate these patients from classical DM. Skin involvement in ASyS does not necessitate increased malignancy surveillance. These findings will inform future ASyS classification criteria and patient management. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/01HNFG70S7T9S4TDXQJD6MZ9PBTest; http://hdl.handle.net/1854/LU-01HNFG70S7T9S4TDXQJD6MZ9PBTest; http://doi.org/10.1093/rheumatology/kead481Test; https://biblio.ugent.be/publication/01HNFG70S7T9S4TDXQJD6MZ9PB/file/01HNFG7FYJ95AT7WVGCPJRDYT0Test |
| DOI: | 10.1093/rheumatology/kead481 |
| الإتاحة: | https://doi.org/10.1093/rheumatology/kead481Test https://biblio.ugent.be/publication/01HNFG70S7T9S4TDXQJD6MZ9PBTest http://hdl.handle.net/1854/LU-01HNFG70S7T9S4TDXQJD6MZ9PBTest https://biblio.ugent.be/publication/01HNFG70S7T9S4TDXQJD6MZ9PB/file/01HNFG7FYJ95AT7WVGCPJRDYT0Test |
| حقوق: | Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5F7F269B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/rheumatology/kead481 |
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