دورية أكاديمية
The effectiveness of dexmedetomidine cardioprotection during vascular surgery in high cardiac risk patients ; Эффективность дексмедетомидиновой кардиопротекции при операциях на сосудах у больных высокого кардиального риска
| العنوان: | The effectiveness of dexmedetomidine cardioprotection during vascular surgery in high cardiac risk patients ; Эффективность дексмедетомидиновой кардиопротекции при операциях на сосудах у больных высокого кардиального риска |
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| المؤلفون: | I. A. Kozlov, D. A. Sokolov, P. A. Lyuboshevsky, И. А. Козлов, Д. А. Соколов, П. А. Любошевский |
| المصدر: | Messenger of ANESTHESIOLOGY AND RESUSCITATION; Том 21, № 2 (2024); 6-17 ; Вестник анестезиологии и реаниматологии; Том 21, № 2 (2024); 6-17 ; 2541-8653 ; 2078-5658 |
| بيانات النشر: | NEW TERRA Publishing House |
| سنة النشر: | 2024 |
| المجموعة: | Messenger of ANESTHESIOLOGY AND RESUSCITATION / Вестник анестезиологии и реаниматологии |
| مصطلحات موضوعية: | некардиальная хирургия, dexmedetomidine, α2-adrenoreceptor agonists, cardiovascular complications, vascular surgery, cardiac risk, non-cardiac surgery, агонисты α2-адренорецепторов, сердечно-сосудистые осложнения, операции на сосудах, кардиальный риск |
| الوصف: | The objective was to study the occurrence of perioperative cardiovascular complications (CVС) and clinical and laboratory cardioprotection parameters in patients treated with dexmedetomidine infusion in perioperative period of vascular surgery.Materials and methods. The study involved 204 patients with high cardiac risk (revised cardiac risk index > 2, risk of perioperative myocardial infarction or cardiac arrest > 1%) who underwent elective vascular surgery. The patients were randomly divided into two groups. Group I patients received perioperative infusion of dexmedetomidine at a dose 0.40 [0.34–0.47] mg/kg/h during 7.0 [6.0–8.0]) hours. Group II was a control group. In the perioperative period, the occurrence of CVC, the blood level of the N-terminal fragment of the prohormone B-type natriuretic peptide (NT-proBNP) and cardiospecific troponin I (cTnI) were analyzed. The data were statistically processed, using the Fisher’s exact test, Mann–Whitney test and logistic regression.Results. Perioperative CVC without taking into account arterial hypotension were recorded in 3 (2.9%) patients in group I and in 14 (13.7%) patients in group II (p = 0.009). Arterial hypotension was recorded in 14 (13.7%) patients in group I and in 5 (4.9%) patients in group II (p = 0.051). Perioperative dexmedetomidine infusion reduced the risk of CVC, except for arterial hypotension (OR 0.1905, 95% CI 0.0530–0.6848, p = 0.011) and increased the risk of arterial hypotension (OR 3.5787, 95% CI 1.1254–11.3796, p = 0.031). The cTnI level in patients of groups I and II was 0.017 [0.011–0.024] and 0.019 [0.011–0.028] ng/ml (p = 0.196) before surgery, 0.02 [0.011–0.029] and 0.02 [0.015–0.039] ng/ml (p = 0.050) after surgery, 0.018 [0.014–0.024] and 0.028 [0.018–0.033] ng/ml (p = 0.0002) before discharge from the hospital. At the same stages, the level of NT-proBNP was 221.5 [193.3–306.5] and 237.8 [171.3–310.1] pg/ml (p = 0.572), 237.0 [205–303.5] and 289.0 [217.5–409.5] pg/ml (p = 0.007), 250.5 [198.8–302.0] and 259.6 [171.0–421.6] ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Russian |
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| DOI: | 10.24884/2078-5658-2024-21-2-6-17 |
| الإتاحة: | https://doi.org/10.24884/2078-5658-2024-21-2-6-17Test https://doi.org/10.24884/2078-5658-2023-20-5-6-16Test https://doi.org/10.24884/2078-5658-2023-20-6-19-27Test https://doi.org/10.24884/2078-5658-2022-20-2-6-16Test https://doi.org/10.21292/2078-5658-2022-19-3-33-40Test https://doi.org/10.1017/S0265021506000378Test https://doi.org/10.1097/00000542-199008000-00007Test https://doi.org/10.1111/j.1365-2044.2007.05306.xTest https://doi.org/10.3390/antiox12061206Test https://doi.org/10.3389/fphar.2019.01641Test |
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| رقم الانضمام: | edsbas.5F78179B |
| قاعدة البيانات: | BASE |
| DOI: | 10.24884/2078-5658-2024-21-2-6-17 |
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