دورية أكاديمية
A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation
| العنوان: | A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation |
|---|---|
| المؤلفون: | Compeer, Ewoud B., Kraus, Felix, Ecker, Manuela, Redpath, Gregory, Amiezer, Mayan, Rother, Nils, Nicovich, Philip R., Kapoor-Kaushik, Natasha, Deng, Qiji, Samson, Guerric P. B., Yang, Zhengmin, Lou, Jieqiong, Carnell, Michael, Vartoukian, Haig, Gaus, Katharina, Rossy, Jérémie |
| المصدر: | Nature Communications ; volume 9, issue 1 ; ISSN 2041-1723 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary |
| الوصف: | Endocytosis of surface receptors and their polarized recycling back to the plasma membrane are central to many cellular processes, such as cell migration, cytokinesis, basolateral polarity of epithelial cells and T cell activation. Little is known about the mechanisms that control the organization of recycling endosomes and how they connect to receptor endocytosis. Here, we follow the endocytic journey of the T cell receptor (TCR), from internalization at the plasma membrane to recycling back to the immunological synapse. We show that TCR triggering leads to its rapid uptake through a clathrin-independent pathway. Immediately after internalization, TCR is incorporated into a mobile and long-lived endocytic network demarked by the membrane-organizing proteins flotillins. Although flotillins are not required for TCR internalization, they are necessary for its recycling to the immunological synapse. We further show that flotillins are essential for T cell activation, supporting TCR nanoscale organization and signaling. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41467-018-04088-w |
| الإتاحة: | https://doi.org/10.1038/s41467-018-04088-wTest https://www.nature.com/articles/s41467-018-04088-w.pdfTest https://www.nature.com/articles/s41467-018-04088-wTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.5F60A87D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-018-04088-w |
|---|