التفاصيل البيبلوغرافية
| العنوان: |
PNA-Based MicroRNA Detection Methodologies |
| المؤلفون: |
Enrico Cadoni, Alex Manicardi, Annemieke Madder |
| المصدر: |
Molecules; Volume 25; Issue 6; Pages: 1296 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2020 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
peptide nucleic acid (PNA), microRNA, fluorescence, templated reactions, nanoparticles, light-triggered, electrochemical biosensors, colorimetric detection |
| جغرافية الموضوع: |
agris |
| الوصف: |
MicroRNAs (miRNAs or miRs) are small noncoding RNAs involved in the fine regulation of post-transcriptional processes in the cell. The physiological levels of these short (20–22-mer) oligonucleotides are important for the homeostasis of the organism, and therefore dysregulation can lead to the onset of cancer and other pathologies. Their importance as biomarkers is constantly growing and, in this context, detection methods based on the hybridization to peptide nucleic acids (PNAs) are gaining their place in the spotlight. After a brief overview of their biogenesis, this review will discuss the significance of targeting miR, providing a wide range of PNA-based approaches to detect them at biologically significant concentrations, based on electrochemical, fluorescence and colorimetric assays. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Chemical Biology; https://dx.doi.org/10.3390/molecules25061296Test |
| DOI: |
10.3390/molecules25061296 |
| الإتاحة: |
https://doi.org/10.3390/molecules25061296Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.5F2F8E96 |
| قاعدة البيانات: |
BASE |
