التفاصيل البيبلوغرافية
| العنوان: |
Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A |
| المؤلفون: |
Mathew, Jobin, Balakrishnan, Savitha, Antony, Sherin, Abraham, Pretty Mary, Paulose, CS |
| المصدر: |
Journal of Biomedical Science ; volume 19, issue 1 ; ISSN 1423-0127 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2012 |
| مصطلحات موضوعية: |
Pharmacology (medical), Biochemistry (medical), Cell Biology, Clinical Biochemistry, Molecular Biology, General Medicine, Endocrinology, Diabetes and Metabolism |
| الوصف: |
Abstact Background Gamma amino butyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex, maintains the inhibitory tones that counter balances neuronal excitation. When this balance is perturbed, seizures may ensue. Methods In the present study, alterations of the general GABA, GABA A and GABA B receptors in the cerebral cortex of the epileptic rat and the therapeutic application of Bacopa monnieri were investigated. Results Scatchard analysis of [ 3 H]GABA, [ 3 H]bicuculline and [ 3 H]baclofen in the cerebral cortex of the epileptic rat showed significant decrease in B max (P < 0.001) compared to control. Real Time PCR amplification of GABA receptor subunits such as GABA Aά1 , GABA Aγ , GABA Aδ , GABA B and GAD where down regulated (P < 0.001) in epileptic rats. GABA Aά5 subunit and Cyclic AMP responsible element binding protein were up regulated. Confocal imaging study confirmed the decreased GABA receptors in epileptic rats. Epileptic rats have deficit in radial arm and Y maze performance. Conclusions Bacopa monnieri and Bacoside-A treatment reverses epilepsy associated changes to near control suggesting that decreased GABA receptors in the cerebral cortex have an important role in epileptic occurrence; Bacopa monnieri and Bacoside-A have therapeutic application in epilepsy management. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1186/1423-0127-19-25 |
| DOI: |
10.1186/1423-0127-19-25.pdf |
| الإتاحة: |
https://doi.org/10.1186/1423-0127-19-25Test |
| رقم الانضمام: |
edsbas.5F038271 |
| قاعدة البيانات: |
BASE |
