دورية أكاديمية
International gestational age-specific centiles for umbilical artery doppler indices: A longitudinal prospective cohort study of the INTERGROWTH-21st project
| العنوان: | International gestational age-specific centiles for umbilical artery doppler indices: A longitudinal prospective cohort study of the INTERGROWTH-21st project |
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| المؤلفون: | Drukker, Lior, Staines-Urias, Eleonora, Villar, José, Barros, Fernando C, Carvalho, Maria, Munim, Shama, McGready, Rose, Nosten, Francois, Berkley, James A, Norris, Shane A, Uauy, Ricardo, Kennedy, Stephen H, Papageorghiou, Aris T |
| المصدر: | Department of Obstetrics & Gynaecology |
| بيانات النشر: | eCommons@AKU |
| سنة النشر: | 2020 |
| المجموعة: | The Aga Khan University: eCommons@AKU |
| مصطلحات موضوعية: | Doppler, INTERBIO, INTERGROWTH-21(st) ultrasound, Antepartum testing, Fetal growth restriction, Fetal well-being, Longitudinal study, Multinational study, Perinatal morbidity, Perinatal mortality, Placenta, Pulsatility index, Reference ranges, Resistance index, Systolic/diastolic ratio, Umbilical artery, Obstetrics and Gynecology |
| الوصف: | Background: Reference values for umbilical artery Doppler indices are used clinically to assess fetal well-being. However, many studies that have produced reference charts have important methodologic limitations, and these result in significant heterogeneity of reported reference ranges.Objectives: To produce international gestational age-specific centiles for umbilical artery Doppler indices based on longitudinal data and the same rigorous methodology used in the original Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project.Study design: In Phase II of the INTERGROWTH-21st Project (the INTERBIO-21st Study), we prospectively continued enrolling pregnant women according to the same protocol from 3 of the original populations in Pelotas (Brazil), Nairobi (Kenya), and Oxford (United Kingdom) that had participated in the Fetal Growth Longitudinal Study. Women with a singleton pregnancy were recruited at weeks' gestation, confirmed by ultrasound measurement of crown-rump length, and then underwent standardized ultrasound every 5±1 weeks until delivery. From 22 weeks of gestation umbilical artery indices (pulsatility index, resistance index, and systolic/diastolic ratio) were measured in a blinded fashion, using identical equipment and a rigorously standardized protocol. Newborn size at birth was assessed using the international INTERGROWTH-21st Standards, and infants had detailed assessment of growth, nutrition, morbidity, and motor development at 1 and 2 years of age. The appropriateness of pooling data from the 3 study sites was assessed using variance component analysis and standardized site differences. Umbilical artery indices were modeled as functions of the gestational age using an exponential, normal distribution with second-degree fractional polynomial smoothing; goodness of fit for the overall models was assessed.Results: Of the women enrolled at the 3 sites, 1629 were eligible for this study; 431 (27%) met the entry criteria for the construction of normative centiles, similar to the proportion ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://ecommons.aku.edu/pakistan_fhs_mc_women_childhealth_obstet_gynaecol/207Test; https://ecommons.aku.edu/context/pakistan_fhs_mc_women_childhealth_obstet_gynaecol/article/1206/viewcontent/American_Journal_of_Obstetrics.pdfTest |
| الإتاحة: | https://ecommons.aku.edu/pakistan_fhs_mc_women_childhealth_obstet_gynaecol/207Test https://ecommons.aku.edu/context/pakistan_fhs_mc_women_childhealth_obstet_gynaecol/article/1206/viewcontent/American_Journal_of_Obstetrics.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.5EE23FD8 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |