دورية أكاديمية
In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset
| العنوان: | In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset |
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| المؤلفون: | Hooli, Shubhada, King, Carina, McCollum, Eric D, Colbourn, Tim, Lufesi, Norman, Mwansambo, Charles, Gregory, Christopher J, Thamthitiwat, Somsak, Cutland, Clare, Madhi, Shabir Ahmed, Nunes, Marta C, Gessner, Bradford D, Hazir, Tabish, Mathew, Joseph L, Addo-Yobo, Emmanuel, Chisaka, Noel, Hassan, Mumtaz, Hibberd, Patricia L, Jeena, Prakash, Lozano, Juan M, MacLeod, William B, Patel, Archana, Thea, Donald M, Nguyen, Ngoc Tuong Vy, Zaman, Syed Ma, Ruvinsky, Raul O, Lucero, Marilla, Kartasasmita, Cissy B, Turner, Claudia, Asghar, Rai, Banajeh, Salem, Iqbal, Imran, Maulen-Radovan, Irene, Mino-Leon, Greta, Saha, Samir K, Santosham, Mathuram, Singhi, Sunit, Awasthi, Shally, Bavdekar, Ashish, Chou, Monidarin, Nymadawa, Pagbajabyn, Pape, Jean-William, Paranhos-Baccala, Glaucia, Picot, Valentina Sanchez, Rakoto-Andrianarivelo, Mala, Rouzier, Vanessa, Russomando, Graciela, Sylla, Mariam, Vanhems, Philippe, Wang, Jianwei, Basnet, Sudha, Strand, Tor A, Neuman, Mark I, Arroyo, Luis Martinez, Echavarria, Marcela, Bhatnagar, Shinjini, Wadhwa, Nitya, Lodha, Rakesh, Aneja, Satinder, Gentile, Angela, Chadha, Mandeep, Hirve, Siddhivinayak, O'Grady, Kerry-Ann F, Clara, Alexey W, Rees, Chris A, Campbell, Harry, Nair, Harish, Falconer, Jennifer, Williams, Linda J, Horne, Margaret, Qazi, Shamim A, Nisar, Yasir Bin, Pneumonia REsearch Partnership to Assess WHO REcommendations (PR |
| المصدر: | International Journal of Infectious Diseases , 129 pp. 240-250. (2023) |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2023 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Chest indrawing, Child, Danger sign, Pneumonia, Pulse oximetry, Under 5, Humans, Female, Infant, Preschool, Hospital Mortality, Oximetry, Malnutrition, World Health Organization, Risk Assessment |
| الوصف: | OBJECTIVES: We determined the pulse oximetry benefit in pediatric pneumonia mortality risk stratification and chest-indrawing pneumonia in-hospital mortality risk factors. METHODS: We report the characteristics and in-hospital pneumonia-related mortality of children aged 2-59 months who were included in the Pneumonia Research Partnership to Assess WHO Recommendations dataset. We developed multivariable logistic regression models of chest-indrawing pneumonia to identify mortality risk factors. RESULTS: Among 285,839 children, 164,244 (57.5%) from hospital-based studies were included. Pneumonia case fatality risk (CFR) without pulse oximetry measurement was higher than with measurement (5.8%, 95% confidence interval [CI] 5.6-5.9% vs 2.1%, 95% CI 1.9-2.4%). One in five children with chest-indrawing pneumonia was hypoxemic (19.7%, 95% CI 19.0-20.4%), and the hypoxemic CFR was 10.3% (95% CI 9.1-11.5%). Other mortality risk factors were younger age (either 2-5 months [adjusted odds ratio (aOR) 9.94, 95% CI 6.67-14.84] or 6-11 months [aOR 2.67, 95% CI 1.71-4.16]), moderate malnutrition (aOR 2.41, 95% CI 1.87-3.09), and female sex (aOR 1.82, 95% CI 1.43-2.32). CONCLUSION: Children with a pulse oximetry measurement had a lower CFR. Many children hospitalized with chest-indrawing pneumonia were hypoxemic and one in 10 died. Young age and moderate malnutrition were risk factors for in-hospital chest-indrawing pneumonia-related mortality. Pulse oximetry should be integrated in pneumonia hospital care for children under 5 years. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10167522/1/1-s2.0-S1201971223000504-main.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10167522Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10167522/1/1-s2.0-S1201971223000504-main.pdfTest https://discovery.ucl.ac.uk/id/eprint/10167522Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.5DE56852 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |