دورية أكاديمية
Clinical Effects of Faecal Microbiota Transplantation as Adjunctive Therapy in Dogs with Chronic Enteropathies—A Retrospective Case Series of 41 Dogs
| العنوان: | Clinical Effects of Faecal Microbiota Transplantation as Adjunctive Therapy in Dogs with Chronic Enteropathies—A Retrospective Case Series of 41 Dogs |
|---|---|
| المؤلفون: | Toresson L., Spillmann T., Pilla R., Ludvigsson U., Hellgren J., Olmedal G., Suchodolski J. S. |
| المساهمون: | L. Toresson, T. Spillmann, R. Pilla, U. Ludvigsson, J. Hellgren, G. Olmedal, J.S. Suchodolski |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | chronic enteropathy, dog, dysbiosi, dysbiosis index, faecal microbiota transplantation, non-responsive enteropathy, Settore VET/05 - Malattie Infettive degli Animali Domestici, Settore VET/08 - Clinica Medica Veterinaria |
| الوصف: | Chronic enteropathies (CE) are common in dogs, but not all affected dogs respond to standard therapy. Successful responses to faecal microbial transplantation (FMT) in dogs with non-responsive CE have been reported in two case series. The objective of this retrospective study was to describe the clinical effects of FMT as an adjunctive therapy in a larger population of dogs with CE. Forty-one dogs aged 0.6–13.0 years (median 5.8) under treatment for CE at one referral animal hospital were included. Dogs were treated with 1–5 (median 3) FMTs as a rectal enema at a dose of 5–7 g/kg body weight. The canine inflammatory bowel disease activity index (CIBDAI) was compared at baseline versus after the last FMT. Stored faecal samples (n = 16) were analysed with the dysbiosis index. CIBDAI at baseline was 2–17 (median 6), which decreased to 1–9 (median 2; p < 0.0001) after FMT. Subsequently, 31/41 dogs responded to treatment, resulting in improved faecal quality and/or activity level in 24/41 and 24/41 dogs, respectively. The dysbiosis index at baseline was significantly lower for good responders versus poor responders (p = 0.043). Results suggest that FMT can be useful as an adjunctive therapy in dogs with poorly responsive CE. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37104426; info:eu-repo/semantics/altIdentifier/wos/WOS:000979401300001; volume:10; issue:4; firstpage:1; lastpage:18; numberofpages:18; journal:VETERINARY SCIENCES; https://hdl.handle.net/2434/1044430Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85153746639 |
| DOI: | 10.3390/vetsci10040271 |
| الإتاحة: | https://doi.org/10.3390/vetsci10040271Test https://hdl.handle.net/2434/1044430Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5DCC91AF |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/vetsci10040271 |
|---|