التفاصيل البيبلوغرافية
| العنوان: |
The effect of GLP-1 receptor agonist lixisenatide on experimental diabetic retinopathy |
| المؤلفون: |
Oezer, Kuebra, Kolibabka, Matthias, Gassenhuber, Johann, Dietrich, Nadine, Fleming, Thomas, Schlotterer, Andrea, Morcos, Michael, Wohlfart, Paulus, Hammes, Hans-Peter |
| المساهمون: |
GRK 1874/2 DIAMICOM, SFB 1118, Sanofi-Aventis Deutschland, European Foundation for the Study of Diabetes, NIH Office of Research Infrastructure Programs, Medizinische Fakultät Mannheim der Universität Heidelberg |
| المصدر: |
Acta Diabetologica ; volume 60, issue 11, page 1551-1565 ; ISSN 1432-5233 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Endocrinology, General Medicine, Endocrinology, Diabetes and Metabolism, Internal Medicine |
| الوصف: |
Aims Glucagon-like peptide-1 receptor agonists are effective treatments for type 2 diabetes, effectively lowering glucose without weight gain and with low risk for hypoglycemia. However, their influence on the retinal neurovascular unit remains unclear. In this study, we analyzed the effects of the GLP-1 RA lixisenatide on diabetic retinopathy. Methods Vasculo- and neuroprotective effects were assessed in experimental diabetic retinopathy and high glucose-cultivated C. elegans, respectively. In STZ-diabetic Wistar rats, acellular capillaries and pericytes (quantitative retinal morphometry), neuroretinal function (mfERG), macroglia (GFAP western blot) and microglia (immunohistochemistry) quantification, methylglyoxal (LC–MS/MS) and retinal gene expressions (RNA-sequencing) were determined. The antioxidant properties of lixisenatide were tested in C. elegans. Results Lixisenatide had no effect on glucose metabolism. Lixisenatide preserved the retinal vasculature and neuroretinal function. The macro- and microglial activation was mitigated. Lixisenatide normalized some gene expression changes in diabetic animals to control levels. Ets2 was identified as a regulator of inflammatory genes. In C. elegans, lixisenatide showed the antioxidative property. Conclusions Our data suggest that lixisenatide has a protective effect on the diabetic retina, most likely due to a combination of neuroprotective, anti-inflammatory and antioxidative effects of lixisenatide on the neurovascular unit. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1007/s00592-023-02135-7 |
| DOI: |
10.1007/s00592-023-02135-7.pdf |
| DOI: |
10.1007/s00592-023-02135-7/fulltext.html |
| الإتاحة: |
https://doi.org/10.1007/s00592-023-02135-7Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.5C9F8A5D |
| قاعدة البيانات: |
BASE |
