التفاصيل البيبلوغرافية
| العنوان: |
Secured delivery of basic fibroblast growth factor using human serum albumin-based protein nanoparticles for enhanced wound healing and regeneration |
| المؤلفون: |
Son, Boram, Kim, Minju, Won, Hyosub, Jung, Ara, Kim, Jihyun, Koo, Yonghoe, Lee, Na Kyeong, Baek, Seung-Ho, Han, Uiyoung, Park, Chun Gwon, Shin, Heungsoo, Gweon, Bomi, Joo, Jinmyoung, Park, Hee Ho |
| المساهمون: |
Institute of Information & communications Technology Planning & Evaluation, Hanyang University, National Research Foundation of Korea, Ministry of Science and ICT, South Korea |
| المصدر: |
Journal of Nanobiotechnology ; volume 21, issue 1 ; ISSN 1477-3155 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Pharmaceutical Science, Applied Microbiology and Biotechnology, Biomedical Engineering, Molecular Medicine, Medicine (miscellaneous), Bioengineering |
| الوصف: |
Background Basic fibroblast growth factor (bFGF) is one of the critical components accelerating angiogenesis and tissue regeneration by promoting the migration of dermal fibroblasts and endothelial cells associated with matrix formation and remodeling in wound healing process. However, clinical applications of bFGF are substantially limited by its unstable nature due to rapid decomposition under physiological microenvironment. Results In this study, we present the bFGF-loaded human serum albumin nanoparticles (HSA-bFGF NPs) as a means of enhanced stability and sustained release platform during tissue regeneration. Spherical shape of the HSA-bFGF NPs with uniform size distribution (polydispersity index < 0.2) is obtained via a simple desolvation and crosslinking process. The HSA-bFGF NPs securely load and release the intact soluble bFGF proteins, thereby significantly enhancing the proliferation and migration activity of human dermal fibroblasts. Myofibroblast-related genes and proteins were also significantly down-regulated, indicating decrease in risk of scar formation. Furthermore, wound healing is accelerated while achieving a highly organized extracellular matrix and enhanced angiogenesis in vivo. Conclusion Consequently, the HSA-bFGF NPs are suggested not only as a delivery vehicle but also as a protein stabilizer for effective wound healing and tissue regeneration. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1186/s12951-023-02053-4 |
| DOI: |
10.1186/s12951-023-02053-4.pdf |
| DOI: |
10.1186/s12951-023-02053-4/fulltext.html |
| الإتاحة: |
https://doi.org/10.1186/s12951-023-02053-4Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.5C613DEE |
| قاعدة البيانات: |
BASE |
