دورية أكاديمية
Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders
| العنوان: | Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders |
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| المؤلفون: | Cagini C., Torroni G., Mariniello M., Di Lascio G., Martone G., Balestrazzi A. |
| المساهمون: | Cagini, C., Torroni, G., Mariniello, M., Di Lascio, G., Martone, G., Balestrazzi, A. |
| سنة النشر: | 2021 |
| المجموعة: | Università degli Studi di Siena: USiena air |
| مصطلحات موضوعية: | Cataract surgery, Dry eye, Post-operative, Trehalose/sodium hyaluronate/carbomer eye drops |
| الوصف: | Purpose Prospective, randomised, open-label, comparative study to evaluate efficacy of trehalose/sodium hyaluronate eye drops for post-operative discomfort and tear film stability in patients undergoing cataract surgery. Methods Patients with healthy ocular surface, subclinical, or mild dry eye were enrolled. Tear breakup time (TBUT), Schirmer test, dry eye symptoms, corneal fluorescein staining (CFS), and ocular surface disease (OSDI) evaluation were performed pre-operatively and at two and four weeks after surgery. Patients were assigned to receive trehalose/sodium hyaluronate eye drops b.i.d (Group A), or 0.9% unpreserved sodium chloride eye drops b.i.d for 4 weeks (Group B). Results One hundred and thirty-five patients were randomised, 66 patients in Group A (73.2 +/- 4.5 years) and 69 patients in Group B (74.3 +/- 3.8 years), 60.8% females. Fifteen patients (8 Group A) were lost at follow-up. Pre-operatively, no between-group differences were observed, and TBUT increased in Group A between the pre-operative and 2 and 4 week evaluations and was higher in group A than in Group B at 4 weeks. Schirmer test and CFS showed an improvement only in Group A four weeks post-operatively. In Group A an improvement was observed after two and four weeks in foreign body and puncture sensation, whilst a difference in blinking discomfort was observed after four weeks. In Group B we observed an improvement in puncture sensation two and four weeks after surgery. Mean OSDI scores differences between the two groups were significant at four weeks. Conclusions Trehalose/sodium hyaluronate eye drops were effective in reducing signs and symptoms of dry eye and improving tear film stability |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33956256; info:eu-repo/semantics/altIdentifier/wos/WOS:000647937400001; volume:41; issue:9; firstpage:3065; lastpage:3071; numberofpages:7; journal:INTERNATIONAL OPHTHALMOLOGY; https://hdl.handle.net/11365/1257277Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85105446057; https://link.springer.com/article/10.1007/s10792-021-01869-zTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364531Test/ |
| DOI: | 10.1007/s10792-021-01869-z |
| الإتاحة: | https://doi.org/10.1007/s10792-021-01869-zTest https://hdl.handle.net/11365/1257277Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364531Test/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5C4630D1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10792-021-01869-z |
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