دورية أكاديمية
Podocyte Antigen Staining to Identify Distinct Phenotypes and Outcomes in Membranous Nephropathy: A Retrospective Multicenter Cohort Study.
| العنوان: | Podocyte Antigen Staining to Identify Distinct Phenotypes and Outcomes in Membranous Nephropathy: A Retrospective Multicenter Cohort Study. |
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| المؤلفون: | Hanset, Nicolas, Aydin, Selda, Demoulin, Nathalie, Cosyns, Jean-Pierre, Castanares Zapatero, Diego, Crott, Ralph, Cambier, Jean-François, Pochet, Jean-Michel, Gillerot, Gaëlle, Reginster, Francois, Houssiau, Frédéric, Debiec, Hanna, Ronco, Pierre, Jadoul, Michel, Morelle, Johann, UCLouvain Kidney Disease Network, Devresse, Arnaud, Gillion, Valentine, Kanaan, Nada, Labriola, Laura, Goffin, Eric, Pirson, Yves, Buysschaert, Benoit |
| المساهمون: | UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - SSS/IREC/MORF - Pôle de Morphologie, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service de soins intensifs, UCL - (SLuc) Service de rhumatologie |
| المصدر: | American journal of kidney diseases, Vol. 76, no. 5, p. 624-635 (2020) |
| بيانات النشر: | W.B. Saunders |
| سنة النشر: | 2020 |
| المجموعة: | DIAL@UCL (Université catholique de Louvain) |
| مصطلحات موضوعية: | Adult, Aged, Autoantibodies, Biopsy, Disease Progression, Female, Follow-Up Studies, Glomerulonephritis, Membranous, Humans, Male, Middle Aged, Phenotype, Podocytes, Retrospective Studies, Staining and Labeling, Membranous nephropathy (MN), cancer, glomerular disease, immunostaining, kidney biopsy, malignancy, nephrotic syndrome, outcome, phospholipase A(2) receptor (PLA(2)R), podocyte antigen, thrombospondin type 1 domain-containing 7A (THSD7A) |
| الوصف: | RATIONALE & OBJECTIVE: Membranous nephropathy (MN) is characterized by the deposition of immune complexes along glomerular basement membranes. M-Type phospholipase A2 receptor (PLA2R), thrombospondin type 1 domain-containing 7A (THSD7A), exostosin 1 and 2 (EXT1/2), and neural epidermal growth factor-like 1 protein (NELL-1) have been identified as established or potential podocyte antigens in MN. We investigated the association of podocyte antigen staining with MN clinical phenotype and outcomes. STUDY DESIGN: Multicenter retrospective cohort study. SETTING & PARTICIPANTS: 177 consecutive patients with MN unrelated to lupus erythematosus, identified after screening of 3,875 native kidney biopsies performed in the Belgian UCLouvain Kidney Disease Network from 2000 through 2018. PREDICTOR: Positive immunostaining for podocyte antigens on archived kidney biopsy samples. OUTCOMES: Association with different phenotypes (baseline characteristics of patients and pathologic findings on kidney biopsy), time to cancer and to kidney failure. ANALYTICAL APPROACH: Kaplan-Meier estimates and Cox regression analyses to assess time to cancer and kidney failure. RESULTS: 177 patients were followed up for a median of 4.0 (IQR, 1.3-8.0) years. Diagnosis of PLA2R-positive (PLA2R+), THSD7A+, and double-negative (PLA2R-/THSD7A-) MN was made in 117 (66.1%), 6 (3.4%), and 54 (30.5%) patients, respectively. Progression to kidney failure was similar in all groups. Although the number of patients with THSD7A+MN was small, they showed a higher incidence (50%) and increased risk for developing cancer during follow-up (adjusted HR, 5.0 [95% CI, 1.4-17.9]; P=0.01). 8% and 5% of patients with double-negative MN stained positively for EXT1/2 and NELL-1, respectively. Most patients with EXT1/2+MN were women, had features of systemic autoimmunity, and showed glomerular C1q deposits. LIMITATIONS: Retrospective design; small number of patients in the THSD7A group; lack of evaluation of immunoglobulin G subclasses deposition. CONCLUSIONS: Our ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0272-6386 1523-6838 |
| العلاقة: | boreal:242467; http://hdl.handle.net/2078.1/242467Test; info:pmid/32668319; urn:ISSN:0272-6386; urn:EISSN:1523-6838 |
| DOI: | 10.1053/j.ajkd.2020.04.013 |
| الإتاحة: | https://doi.org/10.1053/j.ajkd.2020.04.013Test http://hdl.handle.net/2078.1/242467Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5BCE10B1 |
| قاعدة البيانات: | BASE |
| تدمد: | 02726386 15236838 |
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| DOI: | 10.1053/j.ajkd.2020.04.013 |