دورية أكاديمية
The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton
| العنوان: | The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton |
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| المؤلفون: | Rivera Alvarez, José, Asselin, Laure, Tilly, Peggy, Benoit, Roxane, Batisse, Claire, Richert, Ludovic, Batisse, Julien, Morlet, Bastien, Levet, Florian, Schwaller, Noémie, Mély, Yves, Ruff, M., Reymann, Anne-Cécile, Godin, Juliette |
| المساهمون: | Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Bioimagerie et Pathologies (LBP), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Interdisciplinary Institute for Neuroscience Bordeaux (IINS), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Bordeaux Imaging Center (BIC), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ANR-17-EURE-0023,IMCBio,Integrative Molecular and Cellular Biology(2017), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-10-LABX-0030,INRT,Integrative Biology : Nuclear dynamics- Regenerative medicine - Translational medicine(2010), ANR-19-CE13-0005,DeCaNu,Nucleation d'actine sous controle dévelopmental chez C. elegans.(2019) |
| المصدر: | ISSN: 2211-1247. |
| بيانات النشر: | HAL CCSD Elsevier Inc |
| سنة النشر: | 2023 |
| المجموعة: | Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| مصطلحات موضوعية: | Kif21b, actin, cytoskeleton, glia-guided locomotion, kinesin, microtubule, neuronal polarization, nucleokinesis, radial migration, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis |
| الوصف: | International audience ; Completion of neuronal migration is critical for brain development. Kif21b is a plus-end-directed kinesin motor protein that promotes intracellular transport and controls microtubule dynamics in neurons. Here we report a physiological function of Kif21b during radial migration of projection neurons in the mouse developing cortex. In vivo analysis in mouse and live imaging on cultured slices demonstrate that Kif21b regulates the radial glia-guided locomotion of newborn neurons independently of its motility on microtubules. We show that Kif21b directly binds and regulates the actin cytoskeleton both in vitro and in vivo in migratory neurons. We establish that Kif21b-mediated regulation of actin cytoskeleton dynamics influences branching and nucleokinesis during neuronal locomotion. Altogether, our results reveal atypical roles of Kif21b on the actin cytoskeleton during migration of cortical projection neurons. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37418324; hal-04163589; https://hal.science/hal-04163589Test; https://hal.science/hal-04163589/documentTest; https://hal.science/hal-04163589/file/KIf21b-2023.pdfTest; PUBMED: 37418324 |
| DOI: | 10.1016/j.celrep.2023.112744 |
| الإتاحة: | https://doi.org/10.1016/j.celrep.2023.112744Test https://hal.science/hal-04163589Test https://hal.science/hal-04163589/documentTest https://hal.science/hal-04163589/file/KIf21b-2023.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.5BC1DA70 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2023.112744 |
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