دورية أكاديمية
Facile synthesis of bis(hydroxamamide)-based tetradentate ligands for Tc-99m-radiopharmaceutical
| العنوان: | Facile synthesis of bis(hydroxamamide)-based tetradentate ligands for Tc-99m-radiopharmaceutical |
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| المؤلفون: | Xu, H, Chu, TW, Wang, XG, Liu, XQ |
| المساهمون: | Chu, TW (reprint author), Peking Univ, Dept Appl Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China., Peking Univ, Dept Appl Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China. |
| المصدر: | SCI ; EI ; PubMed |
| بيانات النشر: | 应用辐射与同位素 |
| سنة النشر: | 2005 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | tetradentate ligands, Tc-99m complex, labeling, N,N'-ethylene bis(1-(4-nitroimidazole-1-yl)propanhydroxy-iminoamide), N,N'-propylene-bis(1-(4-nitroimidazole-1-yl)-propanhydroxyiminoamide), TC-99M RADIOPHARMACEUTICALS, CHELATING MOIETY, TUMOR HYPOXIA, HYDROXAMAMIDE, COMPLEXES |
| الوصف: | A facile, two-step synthesis of the bis(hydroxamamide)-based tetradentate ligands for (99)mTc-radiopharmaceuticals is described. Firstly, the hydroxamamide was converted to hydroximic acid chloride by reaction with sodium nitrite in hydrochloric acid at 0 degrees C. Secondly, treating the halide with the ethylenediamine or 1,3-propylenediamine in absolute ethanol formed the desired products, NAP-ethylene bis(l-(4-nitroimidazole-1-yl)-propan-hydroxyiminoamide) (1) and N,N'-propylene bis(l-(4-nitroimidazole-1-yl)-propanhydroxyiminoamide) (II). The corresponding Tc-99m complexes showed high yields and were found by paper clectrophoresis to be electrically neutral under physiological conditions. The partition coefficients indicated a distinct difference between the two complexes. (c) 2005 Elsevier Ltd. All rights reserved. ; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000229204000010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Test ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging ; SCI(E) ; EI ; PubMed ; 4 ; ARTICLE ; 6 ; 919-922 ; 62 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0969-8043 |
| العلاقة: | APPLIED RADIATION AND ISOTOPES.2005,62,(6),919-922.; 677493; http://hdl.handle.net/20.500.11897/199803Test; WOS:000229204000010 |
| DOI: | 10.1016/j.apradiso.2004.12.008 |
| الإتاحة: | https://doi.org/20.500.11897/199803Test https://doi.org/10.1016/j.apradiso.2004.12.008Test https://hdl.handle.net/20.500.11897/199803Test |
| رقم الانضمام: | edsbas.5BBEFCA1 |
| قاعدة البيانات: | BASE |
| تدمد: | 09698043 |
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| DOI: | 10.1016/j.apradiso.2004.12.008 |