التفاصيل البيبلوغرافية
| العنوان: |
Proton Pump Inhibitor Use and Associated Infectious Complications in the PICU: Propensity Score Matching Analysis |
| المؤلفون: |
Goyer, Isabelle, Lacotte, Edouard, Montreuil, Julien, Thibon, Pascal, Briant, Anaïs R., Dupont, Claire, Parienti, Jean-Jacques, Brossier, David |
| المصدر: |
Pediatric Critical Care Medicine ; volume 23, issue 12, page e590-e594 ; ISSN 1529-7535 |
| بيانات النشر: |
Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: |
2022 |
| الوصف: |
OBJECTIVES: We aimed to evaluate the association between proton pump inhibitor (PPI) exposure and nosocomial infection (NI) during PICU stay. DESIGN: Propensity score matched analysis of a single-center retrospective cohort from January 1, 2017, to December 31, 2018. SETTING: Tertiary medical and surgical PICU in France. PATIENTS: Patients younger than 18 years old, admitted to the PICU with a stay greater than 48 hours. INTERVENTION: Patients were retrospectively allocated into two groups and compared depending on whether they received a PPI or not. MEASUREMENTS AND MAIN RESULTS: Seven-hundred fifty-four patients were included of which 231 received a PPI (31%). PPIs were mostly used for stress ulcer prophylaxis (174/231; 75%), but upper gastrointestinal bleed risk factors were rarely present (18%). In the unadjusted analyses, the rate of NI was 8% in the PPI exposed group versus 2% in the nonexposed group. After propensity score matching ( n = 184 per group), we failed to identify an association between PPI exposure and greater odds of NI (adjusted odds ratio 2.9 [95% CI, 0.9–9.3]; p = 0.082). However, these data have not excluded the possibility that there is up to nine-fold greater odds of NI. CONCLUSIONS: This study highlights the prevalent use of PPIs in the PICU, and the potential association between PPIs and nine-fold greater odds of NI is not excluded. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1097/pcc.0000000000003063 |
| DOI: |
10.1097/PCC.0000000000003063 |
| الإتاحة: |
https://doi.org/10.1097/pcc.0000000000003063Test |
| رقم الانضمام: |
edsbas.5BA9DB8A |
| قاعدة البيانات: |
BASE |
