دورية أكاديمية
IL-4/IL-13 Inhibitors for Atopic Dermatitis Induce Psoriatic Rash Transcriptionally Close to Pustular Psoriasis
| العنوان: | IL-4/IL-13 Inhibitors for Atopic Dermatitis Induce Psoriatic Rash Transcriptionally Close to Pustular Psoriasis |
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| المؤلفون: | Grolleau, Chloé, Calugareanu, Andreea, Demouche, Sarah, Nosbaum, Audrey, Staumont-Sallé, Delphine, Aubert, Hélène, Cassius, Charles, Jachiet, Marie, Saussine, Anne, Bagot, Martine, Bachelez, Hervé, Battistella, Maxime, Hotz, Claire, Du Thanh, Aurélie, Crépy, Marie-Noëlle, Bergerat, David, Merandet, Marine, Onifarasoaniaina, Rachel, Alberdi, Antonio, How-Kit, Alexandre, Bouaziz, Jean-David, Le-Buanec, Hélène |
| المساهمون: | Service de Dermatologie AP-HP Hôpital Saint-Louis, Hopital Saint-Louis AP-HP (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Dermatologie Lyon, Hôpital Edouard Herriot CHU - HCL, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Institute for Translational Research in Inflammation - U 1286 (INFINITE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Département de Dermatologie CHU Nantes, Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Genetic skin diseases : from disease mechanism to therapies (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Service de pathologie Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris, Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Montpellier, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Service de Dermatologie CHU Cochin, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin AP-HP, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine, ex- Institut Universitaire Hématologie-IUH) (IRSL), Université Paris Cité (UPCité), Fondation Jean Dausset CEPH |
| المصدر: | ISSN: 0022-202X. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | AD, atopic dermatitis DEG, differentially expressed gene DI-Pso, dupilumab-induced psoriatic eruption DC, dendritic cell FDR, false discovery rate GPP, generalized pustular psoriasis GSEA, Gene Set Enrichment Analysis HC, healthy control IPA, Ingenuity Pathway Analysis KC, keratinocyte PSO, plaque psoriasis Th, T helper UR, upstream regulator, atopic dermatitis, DEG, differentially expressed gene, DI-Pso, dupilumab-induced psoriatic eruption, DC, dendritic cell, FDR, false discovery rate, GPP, generalized pustular psoriasis, GSEA, Gene Set Enrichment Analysis, HC, healthy control, IPA |
| الوصف: | International audience ; Dupilumab is a therapeutic antibody targeting IL-4 and IL-13 receptor subunit alpha used for the treatment of patients with atopic dermatitis (AD). Cases of psoriasis-like reactions induced under dupilumab treatment (dupilumab-induced psoriatic eruption [DI-Pso]) for AD were recently reported. To understand the pathogenesis of DI-Pso, we performed gene expression profiling studies on skin biopsies of DI-Pso (n ¼ 7) compared with those of plaque psoriasis, AD, and healthy controls (n ¼ 4 each). Differential gene expression was performed using enrichment and Gene Ontology analysis. Gene expression was validated by qPCR, and protein levels were assessed by immunohistochemistry. Transcriptomic and protein analysis of DI-Pso compared with that of healthy controls, plaque psoriasis, and AD skins revealed activation of T helper 17/IL-23 pathways associated with a significant expression of IL-36, surrogate marker of pustular psoriasis. By contrast, T helper 2 representative genes' expression was strongly decreased in DI-Pso across comparison. Matching analysis with public data of pustular psoriasis skin corroborated that DI-Pso and pustular psoriasis upstream regulators overlap, greater than the overlap with plaque psoriasis. Furthermore, DI-Pso showed strongly decreased expression of many barrier skin genes compared with healthy controls, plaque psoriasis, and AD. Our data indicate that the pathogenesis of DI-Pso relied on a shift of skin immune responses from a T helper 2 to an IL-36 and T helper 17 polarization and on intensified skin barrier alterations. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36610660; inserm-04311288; https://inserm.hal.science/inserm-04311288Test; https://inserm.hal.science/inserm-04311288/documentTest; https://inserm.hal.science/inserm-04311288/file/Grolleau%20C%20Dupi.pdfTest; PUBMED: 36610660 |
| DOI: | 10.1016/j.jid.2022.10.015 |
| الإتاحة: | https://doi.org/10.1016/j.jid.2022.10.015Test https://inserm.hal.science/inserm-04311288Test https://inserm.hal.science/inserm-04311288/documentTest https://inserm.hal.science/inserm-04311288/file/Grolleau%20C%20Dupi.pdfTest |
| رقم الانضمام: | edsbas.5B7D6064 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jid.2022.10.015 |
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