دورية أكاديمية
Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts
| العنوان: | Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts |
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| المؤلفون: | Matilla-Santander, N. (Nuria), Valvi, D. (Damaskini), Lopez-Espinosa, M.-J. (Maria-Jose), Manzano-Salgado, C.B. (Cyntia B.), Ballester, F. (Ferran), Ibarluzea, J.M. (Jesús), Santa-Marina, L. (Loreto), Schettgen, T. (Thomas), Guxens Junyent, M. (Mònica), Sunyer, J. (Jordi), Vrijheid, M. (Martine) |
| المصدر: | Environmental Health Perspectives vol. 125 no. 11 |
| سنة النشر: | 2017 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| الوصف: | BACKGROUND: Exposure to perfluoroalkyl substances (PFASs) may increase risk for metabolic diseases; however, epidemiologic evidence is lacking at the present time. Pregnancy is a period of enhanced tissue plasticity for the fetus and the mother and may be a critical window of PFAS exposure susceptibility.OBJECTIVE: We evaluated the associations between PFAS exposures and metabolic outcomes in pregnant women.METHODS: We analyzed 1,240 pregnant women from the Spanish INMA [Environment and Childhood Project (INfancia y Medio Ambiente)] birth cohort study (recruitment period: 2003-2008) with measured first pregnancy trimester plasma concentrations of four PFASs (in nanograms/milliliter). We used logistic regression models to estimate associations of PFASs (log10-transformed and categorized into quartiles) with impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM), and we used linear regression models to estimate associations with first-trimester serum levels of triglycerides, total cholesterol, and C-reactive protein (CRP).RESULTS: Perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) were positively associated with IGT (137 cases) [OR per log10-unit increase=1.99 (95% |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/grantAgreement/EC/FP7/282957; info:eu-repo/grantAgreement/EC/FP7/261357; http://repub.eur.nl/pub/103914Test; urn:hdl:1765/103914 |
| DOI: | 10.1289/EHP1062 |
| الإتاحة: | https://doi.org/10.1289/EHP1062Test http://repub.eur.nl/pub/103914Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5B79CA3C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1289/EHP1062 |
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