دورية أكاديمية
Clinical course and prognosis of the lymphoproliferative disease of granular lymphocytes. A multicenter study.
| العنوان: | Clinical course and prognosis of the lymphoproliferative disease of granular lymphocytes. A multicenter study. |
|---|---|
| المؤلفون: | PANDOLFI F, LOUGHRAN TP JR, STARKEBAUM G, CHISESI T, BARBUI T, CHAN WC, BROUET JC, DE ROSSI G, MCKENNA RW, F. Herrmann, J. W. Vanoostveen, G. Schlimok, A. Cafaro, R. Zambello, M. C. Garcia Rodriguez, C. H. Geisler, G. Pizzolo, R. G. Steis, J. U. Brisbane, M. E. Kadin, A. Mantovani, S. Tagawa, A. S. Fauci, G. Gastl, M. Palutke, S. J. Proctor, H. F. Pross, P. Mancini, F. Aiuti, G. Semenzato, SALSANO, Felice |
| المساهمون: | Pandolfi, F, LOUGHRAN TP, Jr, Starkebaum, G, Chisesi, T, Barbui, T, Chan, Wc, Brouet, Jc, DE ROSSI, G, Mckenna, Rw, Salsano, Felice, F., Herrmann, J. W., Vanoostveen, G., Schlimok, A., Cafaro, R., Zambello, M. C., Garcia Rodriguez, C. H., Geisler, G., Pizzolo, R. G., Stei, J. U., Brisbane, M. E., Kadin, A., Mantovani, S., Tagawa, A. S., Fauci, G., Gastl, M., Palutke, S. J., Proctor, H. F., Pro, P., Mancini, F., Aiuti, G., Semenzato |
| بيانات النشر: | John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.comTest, Fax: (212)748-6551 |
| سنة النشر: | 1990 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| الوصف: | Lymphoproliferative disease of granular lymphocytes (LDGL) is a recently recognized, relatively rare atypical lymphocytosis characterized by the presence of over 2000 lymphocytes with cytoplasmic azurophilic granules/mm3 in the peripheral blood. The clinical course is heterogeneous, varying from spontaneous regression to progressive, malignant disease. As a consequence, clinical intervention is not standardized. In a worldwide multicenter study, the authors observed 151 patients with LDGL for a mean follow-up time of 29 months. Forty-three patients were asymptomatic at the time of diagnosis. In the remaining cases, clinical symptoms included fever (41 cases), infections (58), neutropenia (47), anemia (17), and thrombocytopenia (12). In 69 cases, LDGL coexisted with an associated disease. Most patients had a nonprogressive clinical course despite the presence of severe symptoms. In 19 patients, death related to LDGL occurred within 48 months. The authors investigated which features at diagnosis were significantly associated with increased mortality. In the univariate analysis, lymph node and liver enlargement, fever at presentation, skin infiltration, a low (less than or equal to 5000/mm3) or high (greater than 20,000/mm3) peripheral leukocyte count, relatively low (less than or equal to 3000) or high (greater than 7000/mm3) absolute peripheral granular lymphocyte (GL) count, and a low (less than or equal to 15%) percentage of HNK-1-positive cells were found to be predictors of increased mortality. In the multivariate analysis, significant independent predictors were fever at diagnosis, a low (less than or equal to 15%) percentage of HNK-1-positive peripheral blood mononuclear cells (PBMC) and a relatively low (less than or equal to 3000) GL count. These results showed that about 25% of the patients with LDGL were diagnosed after a routine blood count and had no clinical symptoms. The remaining patients were symptomatic, with some experiencing a fatal clinical course. The author's analysis of the significant ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/2403836; info:eu-repo/semantics/altIdentifier/wos/WOS:A1990CH75100026; volume:65; issue:2; firstpage:341; lastpage:348; numberofpages:8; journal:CANCER; http://hdl.handle.net/11573/28964Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0025173863; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=A1990CH75100026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest; http://www.scopus.com/inward/record.url?eid=2-s2.0-0025173863&partnerID=65&md5=78e8ba2b5041d4c62d041039a6b6f014Test |
| الإتاحة: | http://hdl.handle.net/11573/28964Test http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=A1990CH75100026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest http://www.scopus.com/inward/record.url?eid=2-s2.0-0025173863&partnerID=65&md5=78e8ba2b5041d4c62d041039a6b6f014Test |
| رقم الانضمام: | edsbas.5B38F9CF |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |