دورية أكاديمية

Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity : The GUSTO study

التفاصيل البيبلوغرافية
العنوان: Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity : The GUSTO study
المؤلفون: Chen, Ling Wei, Ng, Sharon, Tint, Mya Thway, Michael, Navin, Sadananthan, Suresh Anand, Ong, Yi Ying, Yuan, Wen Lun, Chen, Ze Ying, Chen, Chia Yang, Godfrey, Keith M., Tan, Kok Hian, Gluckman, Peter D., Chong, Yap Seng, Eriksson, Johan G., Yap, Fabian, Lee, Yung Seng, Fortier, Marielle V., Velan, Sendhil S., Chan, Shiao Yng
المساهمون: Clinicum, Research Programs Unit, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care
بيانات النشر: Elsevier Scientific Publ. Co
سنة النشر: 2023
المجموعة: Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto
مصطلحات موضوعية: Abdominal adiposity, Birth size, Offspring adiposity, Per- and polyfluoroalkyl substances, PFAS, Prenatal exposure, 3121 General medicine, internal medicine and other clinical medicine
الوصف: Background: The influence of prenatal exposure to per- and poly- fluoroalkyl substances (PFAS) on birth size and offspring adiposity is unclear, especially for the newer, shorter-chained replacement PFAS. Methods: In the GUSTO multi-ethnic Singaporean mother-offspring cohort, 12 PFAS were measured in 783 cord plasma samples using ultra-performance-liquid chromatography-tandem-mass-spectrometer (UPLC-MS/MS). Outcomes included offspring anthropometry, other indicators of body composition/metabolic health, and MRI-derived abdominal adiposity (subset) at birth and 6 years of age. PFAS were modeled individually, in categories of long-chain and short-chain PFAS, and as scores of three principal components (PC) derived using PC analysis (PC1, PC2, and PC3 reflect predominant exposure patterns to “very-long-PFAS”, “long-PFAS”, and “short-PFAS”, respectively). Associations with outcomes were assessed using multivariable linear regressions, adjusted for important covariates such as maternal sociodemographic and lifestyle factors. Results: Overall, cord PFAS levels showed either no or positive associations (mostly for long-chain PFAS) with birth weight, length and head circumference. In general, PFAS were associated with higher neonatal abdominal adiposity, driven by shorter-chain PFAS. Perfluoroheptanoic acid (PFHpA) was associated with higher volumes of superficial subcutaneous adipose tissue (sSAT) (3.75 [1.13, 6.37] mL per SD increase in PFAS) and internal adipose tissue (IAT) (1.39 [0.41, 2.38] mL). Higher levels of perfluorobutanesulfonic acid (PFBS), short-chain PFAS, and PC3 were associated with higher IAT volume (β range 1.22–1.41 mL/SD, all P < 0.02), especially in girls. Higher PC3 score was additionally associated with higher sSAT (3.12 [0.45, 5.80] mL) volume. At age 6 years, most observed associations did not persist. No consistent associations were observed between PFAS and whole-body adiposity measures. Conclusions: Fetal exposure to emerging short-chain PFAS was associated with higher abdominal ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
العلاقة: This research is supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health’s National Medical Research Council (NMRC), Singapore - NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014 . Additional funding is provided by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore. K.M.G. is supported by the UK Medical Research Council ( MC_UU_12011/4 ) and the National Institute for Health Research (NIHR Senior Investigator ( NF-SI-0515-10042 ) and NIHR Southampton Biomedical Research Centre ( NIHR203319 )). L.W.C. is supported by a grant ( MOST110-2314-B-002-290-MY2; P110A290 ) from the Ministry of Science and Technology (now the National Science and Technology Council) and receives further financial support from the National Taiwan University Higher Education Sprout Project ( 111L7304 , 111L7306 , 110L7418 , 110L881002 ) within the framework of the Higher Education Sprout Project by the Ministry of Education in Taiwan. For the purpose of Open Access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission. The authors would like to thank the GUSTO study group, which includes Allan Sheppard, Amutha Chinnadurai, Anne Eng Neo Goh, Anne Rifkin-Graboi, Anqi Qiu, Arijit Biswas, Bee Wah Lee, Birit F.P. Broekman, Boon Long Quah, Borys Shuter, Chai Kiat Chng, Cheryl Ngo, Choon Looi Bong, Christiani Jeyakumar Henry, Claudia Chi, Cornelia Yin Ing Chee, Yam Thiam Daniel Goh, Doris Fok, E Shyong Tai, Elaine Tham, Elaine Quah Phaik Ling, Evelyn Chung Ning Law, Evelyn Xiu Ling Loo, Fabian Yap, Falk Mueller-Riemenschneider, George Seow Heong Yeo, Helen Chen, Heng Hao Tan, Hugo P S van Bever, Iliana Magiati, Inez Bik Yun Wong, Ivy Yee-Man Lau, Izzuddin Bin Mohd Aris, Jeevesh Kapur, Jenny L. Richmond, Jerry Kok Yen Chan, Joanna D. Holbrook, Joanne Yoong, Joao N. Ferreira. Jonathan Tze Liang Choo, Jonathan Y. Bernard, Joshua J. Gooley, Keith M. Godfrey, Kenneth Kwek, Kok Hian Tan, Krishnamoorthy Niduvaje, Kuan Jin Lee, Leher Singh, Lieng Hsi Ling, Lin Lin Su, Ling-Wei Chen, Lourdes Mary Daniel, Lynette P Shek, Marielle V. Fortier, Mark Hanson, Mary Foong-Fong Chong, Mary Rauff, Mei Chien Chua, Melvin Khee-Shing Leow, Michael Meaney, Mya Thway Tint, Neerja Karnani, Ngee Lek, Oon Hoe Teoh, P. C. Wong, Paulin Tay Straughan, Peter D. Gluckman, Pratibha Agarwal, Queenie Ling Jun Li, Rob M. van Dam, Salome A. Rebello, Seang-Mei Saw, See Ling Loy, S. Sendhil Velan, Seng Bin Ang, Shang Chee Chong, Sharon Ng, Shiao-Yng Chan, Shirong Cai, Shu-E Soh, Sok Bee Lim, Stella Tsotsi, Chin-Ying Stephen Hsu, Sue Anne Toh, Swee Chye Quek, Victor Samuel Rajadurai, Walter Stunkel, Wayne Cutfield, Wee Meng Han, Wei Wei Pang, Yap-Seng Chong, Yin Bun Cheung, Yiong Huak Chan and Yung Seng Lee. L.W.C. S.N. and S.Y.C. conceptualized the current study. L.W.C. conducted formal statistical analysis and wrote the first draft of the manuscript. S.N, M.T.T. N.M. S.A.S. Y.Y.O. and W.L.Y. contributed to data acquisition and curation. Z.Y.C. and C.Y.C. performed PFAS analyses. K.M.G. K.H.T. P.D.G. Y.S.C, J.G.E. F.Y. Y.S.L. M.V.F. S.S.V. and S.Y.C. designed and led the GUSTO cohort study. All authors interpreted the findings and revised drafts of the manuscript. All authors read and approved the final version of the manuscript submitted for publication. This research is supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health's National Medical Research Council (NMRC), Singapore - NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014. Additional funding is provided by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore. K.M.G. is supported by the UK Medical Research Council (MC_UU_12011/4) and the National Institute for Health Research (NIHR Senior Investigator (NF-SI-0515-10042) and NIHR Southampton Biomedical Research Centre (NIHR203319)). L.W.C. is supported by a grant (MOST110-2314-B-002-290-MY2; P110A290) from the Ministry of Science and Technology (now the National Science and Technology Council) and receives further financial support from the National Taiwan University Higher Education Sprout Project (111L7304, 111L7306, 110L7418, 110L881002) within the framework of the Higher Education Sprout Project by the Ministry of Education in Taiwan. For the purpose of Open Access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission.; Chen , L W , Ng , S , Tint , M T , Michael , N , Sadananthan , S A , Ong , Y Y , Yuan , W L , Chen , Z Y , Chen , C Y , Godfrey , K M , Tan , K H , Gluckman , P D , Chong , Y S , Eriksson , J G , Yap , F , Lee , Y S , Fortier , M V , Velan , S S & Chan , S Y 2024 , ' Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity : The GUSTO study ' , Environment International , vol. 183 , 108340 . https://doi.org/10.1016/j.envint.2023.108340Test; 85178149964; 29501a63-d152-4f62-b77f-6a6df3b217d8; http://hdl.handle.net/10138/568838Test
الإتاحة: http://hdl.handle.net/10138/568838Test
حقوق: cc_by_nc_nd ; openAccess ; info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.5B346B18
قاعدة البيانات: BASE