دورية أكاديمية
T Cell Extracellular Traps: Tipping the Balance Between Skin Health and Disease
| العنوان: | T Cell Extracellular Traps: Tipping the Balance Between Skin Health and Disease |
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| المؤلفون: | Kelsey Ouyang, Nicole Oparaugo, Amanda M. Nelson, George W. Agak |
| المصدر: | Frontiers in Immunology, Vol 13 (2022) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | T cell extracellular traps, acne, Cutibacterium acnes (C acnes), TH17 cell, skin, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | The role of extracellular traps (ETs) in the innate immune response against pathogens is well established. ETs were first identified in neutrophils and have since been identified in several other immune cells. Although the mechanistic details are not yet fully understood, recent reports have described antigen-specific T cells producing T cell extracellular traps (TETs). Depending on their location within the cutaneous environment, TETs may be beneficial to the host by their ability to limit the spread of pathogens and provide protection against damage to body tissues, and promote early wound healing and degradation of inflammatory mediators, leading to the resolution of inflammatory responses within the skin. However, ETs have also been associated with worse disease outcomes. Here, we consider host-microbe ET interactions by highlighting how cutaneous T cell-derived ETs aid in orchestrating host immune responses against Cutibacterium acnes (C. acnes), a commensal skin bacterium that contributes to skin health, but is also associated with acne vulgaris and surgical infections following joint-replacement procedures. Insights on the role of the skin microbes in regulating T cell ET formation have broad implications not only in novel probiotic design for acne treatment, but also in the treatment for other chronic inflammatory skin disorders and autoimmune diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1664-3224 |
| العلاقة: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.900634/fullTest; https://doaj.org/toc/1664-3224Test; https://doaj.org/article/b17fc774cf1544f79c625df237554f71Test |
| DOI: | 10.3389/fimmu.2022.900634 |
| الإتاحة: | https://doi.org/10.3389/fimmu.2022.900634Test https://doaj.org/article/b17fc774cf1544f79c625df237554f71Test |
| رقم الانضمام: | edsbas.5AFCBBDB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16643224 |
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| DOI: | 10.3389/fimmu.2022.900634 |