دورية أكاديمية
Evolution of gene dosage on the Z-chromosome of schistosome parasites
| العنوان: | Evolution of gene dosage on the Z-chromosome of schistosome parasites |
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| المؤلفون: | Picard, Marion A. L., Cosseau, Celine, Ferre, Sabrina, Quack, Thomas, Grevelding, Christoph G., Coute, Yohann, Vicoso, Beatriz |
| المصدر: | Elife (2050-084X) (Elife Sciences Publications Ltd), 2018-07 , Vol. 7 , N. e35684 , P. 36p. |
| بيانات النشر: | Elife Sciences Publications Ltd |
| سنة النشر: | 2018 |
| المجموعة: | Ifremer (French Research Institute for Exploitation of the Sea): Archimer |
| الوصف: | XY systems usually show chromosome-wide compensation of X-linked genes, while in many ZW systems, compensation is restricted to a minority of dosage-sensitive genes. Why such differences arose is still unclear. Here, we combine comparative genomics, transcriptomics and proteomics to obtain a complete overview of the evolution of gene dosage on the Z-chromosome of Schistosoma parasites. We compare the Z-chromosome gene content of African (Schistosoma mansoni and S. haematobium) and Asian (S. japonicum) schistosomes and describe lineage-specific evolutionary strata. We use these to assess gene expression evolution following sex-linkage. The resulting patterns suggest a reduction in expression of Z-linked genes in females, combined with upregulation of the Z in both sexes, in line with the first step of Ohno's classic model of dosage compensation evolution. Quantitative proteomics suggest that post-transcriptional mechanisms do not play a major role in balancing the expression of Z-linked genes. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://archimer.ifremer.fr/doc/00454/56588/71845.pdfTest; https://archimer.ifremer.fr/doc/00454/56588Test/ |
| DOI: | 10.7554/eLife.35684 |
| الإتاحة: | https://doi.org/10.7554/eLife.35684Test https://archimer.ifremer.fr/doc/00454/56588/71845.pdfTest https://archimer.ifremer.fr/doc/00454/56588Test/ |
| حقوق: | info:eu-repo/semantics/openAccess ; restricted use |
| رقم الانضمام: | edsbas.5AED801F |
| قاعدة البيانات: | BASE |
| DOI: | 10.7554/eLife.35684 |
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