دورية أكاديمية
Effects of Combined Calcium and Vitamin D Supplementation on Insulin Secretion, Insulin Sensitivity and beta-Cell Function in Multi-Ethnic Vitamin D-Deficient Adults at Risk for Type 2 Diabetes: A Pilot Randomized, Placebo-Controlled Trial
| العنوان: | Effects of Combined Calcium and Vitamin D Supplementation on Insulin Secretion, Insulin Sensitivity and beta-Cell Function in Multi-Ethnic Vitamin D-Deficient Adults at Risk for Type 2 Diabetes: A Pilot Randomized, Placebo-Controlled Trial |
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| المؤلفون: | Gagnon, C, Daly, RM, Carpentier, A, Lu, ZX, Shore-Lorenti, C, Sikaris, K, Jean, S, Ebeling, PR |
| المساهمون: | Berthold, HK |
| بيانات النشر: | PUBLIC LIBRARY SCIENCE |
| سنة النشر: | 2014 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | OBJECTIVES: To examine whether combined vitamin D and calcium supplementation improves insulin sensitivity, insulin secretion, β-cell function, inflammation and metabolic markers. DESIGN: 6-month randomized, placebo-controlled trial. PARTICIPANTS: Ninety-five adults with serum 25-hydroxyvitamin D [25(OH)D] ≤55 nmol/L at risk of type 2 diabetes (with prediabetes or an AUSDRISK score ≥15) were randomized. Analyses included participants who completed the baseline and final visits (treatment n = 35; placebo n = 45). INTERVENTION: Daily calcium carbonate (1,200 mg) and cholecalciferol [2,000-6,000 IU to target 25(OH)D >75 nmol/L] or matching placebos for 6 months. MEASUREMENTS: Insulin sensitivity (HOMA2%S, Matsuda index), insulin secretion (insulinogenic index, area under the curve (AUC) for C-peptide) and β-cell function (Matsuda index x AUC for C-peptide) derived from a 75 g 2-h OGTT; anthropometry; blood pressure; lipid profile; hs-CRP; TNF-α; IL-6; adiponectin; total and undercarboxylated osteocalcin. RESULTS: Participants were middle-aged adults (mean age 54 years; 69% Europid) at risk of type 2 diabetes (48% with prediabetes). Compliance was >80% for calcium and vitamin D. Mean serum 25(OH)D concentration increased from 48 to 95 nmol/L in the treatment group (91% achieved >75 nmol/L), but remained unchanged in controls. There were no significant changes in insulin sensitivity, insulin secretion and β-cell function, or in inflammatory and metabolic markers between or within the groups, before or after adjustment for potential confounders including waist circumference and season of recruitment. In a post hoc analysis restricted to participants with prediabetes, a significant beneficial effect of vitamin D and calcium supplementation on insulin sensitivity (HOMA%S and Matsuda) was observed. CONCLUSIONS: Daily vitamin D and calcium supplementation for 6 months may not change OGTT-derived measures of insulin sensitivity, insulin secretion and β-cell function in multi-ethnic adults with low vitamin D status ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | pii: PONE-D-14-25424; Gagnon, C., Daly, R. M., Carpentier, A., Lu, Z. X., Shore-Lorenti, C., Sikaris, K., Jean, S. & Ebeling, P. R. (2014). Effects of Combined Calcium and Vitamin D Supplementation on Insulin Secretion, Insulin Sensitivity and beta-Cell Function in Multi-Ethnic Vitamin D-Deficient Adults at Risk for Type 2 Diabetes: A Pilot Randomized, Placebo-Controlled Trial. PLOS ONE, 9 (10), https://doi.org/10.1371/journal.pone.0109607Test.; http://hdl.handle.net/11343/263323Test |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0109607Test http://hdl.handle.net/11343/263323Test |
| حقوق: | CC BY ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.5AECD066 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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