دورية أكاديمية
Proteasome inhibition by bortezomib parallels a reduction in head and neck cancer cells growth, and an increase in tumor-infiltrating immune cells
| العنوان: | Proteasome inhibition by bortezomib parallels a reduction in head and neck cancer cells growth, and an increase in tumor-infiltrating immune cells |
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| المؤلفون: | Benvenuto, Monica, Ciuffa, Sara, Focaccetti, Chiara, Sbardella, Diego, Fazi, Sara, Scimeca, Manuel, Tundo, Grazia Raffaella, Barillari, Giovanni, Segni, Maria, Bonanno, Elena, Manzari, Vittorio, Modesti, Andrea, Masuelli, Laura, Coletta, Massimo, Bei, Roberto |
| المساهمون: | Benvenuto, M, Ciuffa, S, Focaccetti, C, Sbardella, D, Fazi, S, Scimeca, M, Tundo, Gr, Barillari, G, Segni, M, Bonanno, E, Manzari, V, Modesti, A, Masuelli, L, Coletta, M, Bei, R |
| سنة النشر: | 2021 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | Settore MED/04 - PATOLOGIA GENERALE, Settore MED/05 - PATOLOGIA CLINICA, Settore MED/08 - ANATOMIA PATOLOGICA, Settore BIO/10 - BIOCHIMICA |
| الوصف: | Head and neck cancer (HNC) has frequently an aggressive course for the development of resistance to standard chemotherapy. Thus, the use of innovative therapeutic drugs is being assessed. Bortezomib is a proteasome inhibitor with anticancer effects. In vitro antitumoral activity of Bortezomib was investigated employing human tongue (SCC-15, CAL-27), pharynx (FaDu), salivary gland (A-253) cancer cell lines and a murine cell line (SALTO-5) originated from a salivary gland adenocarcinoma arising in BALB-neuT male mice transgenic for the oncogene neu. Bortezomib inhibited cell proliferation, triggered apoptosis, modulated the expression and activation of pro-survival signaling transduction pathways proteins activated by ErbB receptors and inhibited proteasome activity in vitro. Intraperitoneal administration of Bortezomib delayed tumor growth of SALTO-5 cells transplanted in BALB-neuT mice, protracted mice survival and adjusted tumor microenvironment by increasing tumor-infiltrating immune cells (CD4+ and CD8+ T cells, B lymphocytes, macrophages, and Natural Killer cells) and by decreasing vessels density. In addition, Bortezomib modified the expression of proteasome structural subunits in transplanted SALTO-5 cells. Our findings further support the use of Bortezomib for the treatment of HNC and reveal its ineffectiveness in counteracting the activation of deregulated specific signaling pathways in HNC cell lines when resistance to proteasome inhibition is developed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34561494; info:eu-repo/semantics/altIdentifier/wos/WOS:000698985300044; volume:11; issue:1; numberofpages:23; journal:SCIENTIFIC REPORTS; http://hdl.handle.net/2108/279465Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85115687575 |
| DOI: | 10.1038/s41598-021-98450-6 |
| الإتاحة: | https://doi.org/10.1038/s41598-021-98450-6Test http://hdl.handle.net/2108/279465Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5AE688F0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-021-98450-6 |
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