التفاصيل البيبلوغرافية
| العنوان: |
Cardioprotective effects of ( E)-4-hydroxy-N′-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide: a newly synthesized coumarin hydrazone against isoproterenol-induced myocardial infarction in a rat model |
| المؤلفون: |
Ghazouani, Lakhdar, Khdhiri, Emna, Elmufti, Afoua, Feriani, Anouar, Tir, Meriam, Baaziz, Intissar, Hajji, Raouf, Ben Mansour, Hedi, Ammar, Houcine, Abid, Souhir, Mnafgui, Kais |
| المصدر: |
Canadian Journal of Physiology and Pharmacology ; volume 97, issue 10, page 989-998 ; ISSN 0008-4212 1205-7541 |
| بيانات النشر: |
Canadian Science Publishing |
| سنة النشر: |
2019 |
| الوصف: |
The current study was carried out to evaluate the effect of pretreatment and co-treatment with a newly synthesized coumarin hydrazone, (E)-4-hydroxy-N′-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide (hereinafter EK6), against isoproterenol-induced myocardial infarction in rats. Changes in biochemistry, cardiac biomarkers, electrocardiography, and histopathology after treatment with EK6 or acenocoumarol (Sintrom) were studied. Animals were randomly divided into 4 groups: vehicle control (C), isoproterenol + Sintrom (ISO + Sin), isoproterenol + EK6 (ISO + EK6), and isoproterenol (ISO). Myocardial infarction was induced by subcutaneous ISO administration at a dose of 85 mg·kg –1 ·day –1 with a drug-free interval of 24 h on days 6 and 7. Treatment with ISO led to significant elevation (p < 0.05) in serum levels of cardiac injury biomarkers, namely cardiac troponin-T, lactate dehydrogenase, creatine kinase-MB, alanine aminotransferase, and aspartate aminotransferase compared with levels in the vehicle control. A change in the lipid profile was also observed as a significant increase in total cholesterol and triglycerides. Furthermore, ISO caused significant alterations in the electrocardiogram pattern, including significant ST-segment elevation, significant decreased R wave amplitude, and significant increase in heart rate (16%) as well as marked changes in the histopathology of the heart tissue. Pretreatment and co-treatment with newly synthesized coumarin hydrazone restored all ISO-induced biochemical, lipid, cardiac, and histopathological changes in rats with myocardial infarction. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1139/cjpp-2019-0085 |
| الإتاحة: |
https://doi.org/10.1139/cjpp-2019-0085Test |
| حقوق: |
http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMiningTest |
| رقم الانضمام: |
edsbas.5ADC2152 |
| قاعدة البيانات: |
BASE |
