دورية أكاديمية
Perspectives on optimal control of varicella and herpes zoster by mass routine varicella vaccination
العنوان: | Perspectives on optimal control of varicella and herpes zoster by mass routine varicella vaccination |
---|---|
المؤلفون: | Betta, Monica, Laurino, Marco, Pugliese, Andrea, Guzzetta, Giorgio, LANDI, ALBERTO, MANFREDI, PIETRO ANGELO MANFREDO FRANCESCO |
المساهمون: | Betta, Monica, Laurino, Marco, Pugliese, Andrea, Guzzetta, Giorgio, Landi, Alberto, Manfredi, PIETRO ANGELO MANFREDO FRANCESCO |
سنة النشر: | 2016 |
المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
مصطلحات موضوعية: | Herpes zoster, Immunity boosting, Mass vaccination, Optimal control, Varicella, Adolescent, Adult, Chickenpox, Child, Preschool, Europe, Herpesvirus 3, Human, Middle Aged, Models, Theoretical, Young Adult, Medicine (all), Immunology and Microbiology (all), Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all) |
الوقت: | 2300 |
الوصف: | Herpes zoster arises from reactivation of the varicella–zoster virus (VZV), causing varicella in children. As reactivation occurs when cell-mediated immunity (CMI) declines, and there is evidence that re-exposure to VZV boosts CMI, mass varicella immunization might increase the zoster burden, at least for some decades. Fear of this natural zoster boom is the main reason for the paralysis of varicella immunization in Europe. We apply optimal control to a realistically parametrized age-structured model for VZV transmission and reactivation to investigate whether feasible varicella immunization paths that are optimal in controlling both varicella and zoster exist. We analyse the optimality system numerically focusing on the role of the cost functional, of the relative zoster–varicella cost and of the planning horizon length. We show that optimal programmes will mostly be unfeasible for public health owing to their complex temporal profiles. This complexity is the consequence of the intrinsically antagonistic nature of varicella immunization programmes when aiming to control both varicella and zoster. However, we show that gradually increasing—hence feasible—vaccination schedules can perform better than routine programmes with constant vaccine uptake. Finally,we showthe optimal profiles of feasible programmes targeting mitigation of the post-immunization natural zoster boom with priority. |
نوع الوثيقة: | article in journal/newspaper |
وصف الملف: | ELETTRONICO |
اللغة: | English |
العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26984627; info:eu-repo/semantics/altIdentifier/wos/WOS:000374921900005; volume:283; issue:1826; numberofpages:8; journal:PROCEEDINGS - ROYAL SOCIETY. BIOLOGICAL SCIENCES; http://hdl.handle.net/11568/827758Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84962487823; http://rspb.royalsocietypublishing.org/content/283/1826/20160054.full.pdfTest |
DOI: | 10.1098/rspb.2016.0054 |
الإتاحة: | https://doi.org/10.1098/rspb.2016.0054Test http://hdl.handle.net/11568/827758Test http://rspb.royalsocietypublishing.org/content/283/1826/20160054.full.pdfTest |
حقوق: | info:eu-repo/semantics/openAccess |
رقم الانضمام: | edsbas.5AA17553 |
قاعدة البيانات: | BASE |
DOI: | 10.1098/rspb.2016.0054 |
---|