دورية أكاديمية
Bivalirudin or unfractionated heparin in patients with acute coronary syndromes managed invasively with and without ST elevation (MATRIX): randomised controlled trial
| العنوان: | Bivalirudin or unfractionated heparin in patients with acute coronary syndromes managed invasively with and without ST elevation (MATRIX): randomised controlled trial |
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| المؤلفون: | Leonardi, Sergio, Frigoli, Enrico, Rothenbühler, Martina, Navarese, Eliano, Calabró, Paolo, Bellotti, Paolo, Briguori, Carlo, Ferlini, Marco, Cortese, Bernardo, Lupi, Alessandro, Lerna, Salvatore, Zavallonito-Parenti, Dennis, Esposito, Giovanni, Tresoldi, Simone, Zingarelli, Antonio, Rigattieri, Stefano, Palmieri, Cataldo, Liso, Armando, Abate, Fabio, Zimarino, Marco, Comeglio, Marco, Gabrielli, Gabriele, Chieffo, Alaide, Brugaletta, Salvatore, Mauro, Ciro, Van Mieghem, Nicolas M, Heg, Dik, Jüni, Peter, Windecker, Stephan, Valgimigli, Marco, Maria Salomone, Enrico Frigoli, Pierpaolo Occhilupo, Veronica Lodolini, Monia Monti, Maria Grazia Mazzone, Erika Delos, Maria Teresa Caruso, Maggie Testa, Nestor Ciociano, Maurizio Lazzero, Davide Gazzotti, Lorenzo Cagliari, Leila Shahmohammadi, Martina Caiazza, Vittorio Virga, Elena Guerra, Eva Michalska, Sara Castellini, Vincenzo Serino, Gabriella Visconti, Gianluca Pendenza, Monica Portolan, Marco Anzini, Elisa Silvetti, Tiziana Coco, Francesco Costa, Sara Ariotti, Linda Valli, Marianna Adamo, Marcello Marino, Pascal Vranckx, Sergio Leonardi, Pierluigi Tricoci, Peter Jüni, Martina Rothenbühler, Dik Heg, Marco Valgimigli, Andrea Gagnor, Paolo Calabrò, Paolo Rubartelli, Stefano Garducci, Giuseppe Andò, Andrea Santarelli, Mario Galli, Roberto Garbo, Ezio Bramucci, Salvatore Ierna, Carlo Briguori, Bernardo Cortese, Ugo Limbruno, Roberto Violini, Patrizia Presbitero, Nicoletta de Cesare, Paolo Sganzerla, Arturo Ausiello, Paolo Tosi, Gennaro Sardella, Manel Sabate', Salvatore Brugaletta, Giovanni Saccone, Pietro Vandoni, Antonio Zingarelli, Armando Liso, Stefano Rigattieri, Sandro Pertini, Emilio Di Lorenzo, Carlo Vigna, Cataldo Palmieri, Camillo Falcone, Raffaele De Caterina, Marcello Caputo, Annunziata Chieti, Giovanni Esposito, Alessandro Lupi, Pietro Mazzarotto, Fernando Varbella, Tiziana Zaro, Marco Nazzaro, Sunil V Rao, Arnoud W J van't Hof, Elmir Omerovic, Gianluca Campo, Lucia Uguccioni, Marche Nord, Corrado Tamburino, Dennis Zavalloni-Parenti, Fabio Ferrari, Roberto Ceravolo, Fabio Tarantino, Giampaolo Pasquetto, Gavino Casu, Stefano Mameli, Maria Letizia Stochino, Alberto Cremonesi, Francesco Saia, Fabio Abate, Andrea Picchi, Salvatore Colangelo, Giacomo Boccuzzi, Vincenzo Guiducci, Ferdinando Varbella, Stefano Tresoldi, Marco Contarini, Antonio Dellavalle, Salvatore Curello, Fabio Mangiacapra, Rosario Evola, Francesco Liistro, Manuela Creaco, Antonio Colombo, Alaide Chieffo, Andrea Perkan, Stefano De Servi, Dionigi Fischetti, Alessandro Sciahbasi, Edoardo Pucci, Enrico Romagnoli, Claudio Moretti, Luciano Moretti, Marco Zimmarino, Maurizio Ferrario, Maurizio Turturo, Roberto Bonmassari, Carlo Penzo, Bruno Loi, Ciro Mauro, Anna Sonia Petronio, Gabriele Gabrielli, Antonio Micari, Flavia Belloni, Francesco Amico, Marco Comeglio, Claudio Fresco, Nicolas Van Mieghem, Roberto Diletti, Evelyn Regar, Manel Sabaté, Joan Antoni Gómez, José Francisco Díaz Fernández, Juan Ramón Jiménez, Vicente Mainar, Jose Maria de la Torre Hernandez |
| المساهمون: | Leonardi, Sergio, Frigoli, Enrico, Rothenbühler, Martina, Navarese, Eliano, Calabró, Paolo, Bellotti, Paolo, Briguori, Carlo, Ferlini, Marco, Cortese, Bernardo, Lupi, Alessandro, Lerna, Salvatore, Zavallonito-Parenti, Denni, Esposito, Giovanni, Tresoldi, Simone, Zingarelli, Antonio, Rigattieri, Stefano, Palmieri, Cataldo, Liso, Armando, Abate, Fabio, Zimarino, Marco, Comeglio, Marco, Gabrielli, Gabriele, Chieffo, Alaide, Brugaletta, Salvatore, Mauro, Ciro, Van Mieghem, Nicolas M, Heg, Dik, Jüni, Peter, Windecker, Stephan, Valgimigli, Marco, Salomone, Maria, Occhilupo, Pierpaolo, Lodolini, Veronica, Monti, Monia, Maria Grazia Mazzone, Delos, Erika, Maria Teresa Caruso, Testa, Maggie, Ciociano, Nestor, Lazzero, Maurizio, Gazzotti, Davide, Cagliari, Lorenzo, Shahmohammadi, Leila, Caiazza, Martina, Virga, Vittorio, Guerra, Elena, Michalska, Eva, Castellini, Sara, Serino, Vincenzo, Visconti, Gabriella, Pendenza, Gianluca, Portolan, Monica, Anzini, Marco, Silvetti, Elisa, Coco, Tiziana, Costa, Francesco, Ariotti, Sara, Valli, Linda, Adamo, Marianna, Marino, Marcello, Vranckx, Pascal, Tricoci, Pierluigi, Gagnor, Andrea, Calabrò, Paolo, Rubartelli, Paolo, Garducci, Stefano, Andò, Giuseppe, Santarelli, Andrea, Galli, Mario, Garbo, Roberto, Bramucci, Ezio, Ierna, Salvatore, Limbruno, Ugo, Violini, Roberto, Presbitero, Patrizia, Nicoletta de Cesare, Sganzerla, Paolo, Ausiello, Arturo, Tosi, Paolo, Sardella, Gennaro, Sabate', Manel, Saccone, Giovanni, Vandoni, Pietro, Pertini, Sandro, Emilio Di Lorenzo, Vigna, Carlo, Falcone, Camillo |
| سنة النشر: | 2016 |
| المجموعة: | Università degli Studi di Messina: IRIS |
| الوصف: | Objective: To test the optimal antithrombotic regimen in patients with acute coronary syndrome. Design: Randomised controlled trial. Setting: Patients with acute coronary syndrome with and without ST segment elevation in 78 centres in Italy, the Netherlands, Spain, and Sweden. Participants: 7213 patients with acute coronary syndrome and planned percutaneous coronary intervention: 4010 with ST segment elevation and 3203 without ST segment elevation. The primary study results in the overall population have been reported previously. Interventions: Patients were randomly assigned, in an open label fashion, to one of two regimens: bivalirudin with glycoprotein IIb/IIIa inhibitors restricted to procedural complications or heparin with or without glycoprotein IIb/IIIa inhibitors. Main outcome measures: Primary endpoints were the occurrence of major adverse cardiovascular events, defined as death, myocardial infarction or stroke; and net adverse clinical events, defined as major bleeding or major adverse cardiovascular events, both assessed at 30 days. Analyses were performed by the principle of intention to treat. Results: Use of a glycoprotein IIb/IIIa inhibitor in patients assigned to heparin was planned at baseline in 30.7% of patients with ST segment elevation, in 10.9% without ST segment elevation, and in no patients assigned to bivalirudin. In patients with ST segment elevation, major adverse cardiovascular events occurred in 118 (5.9%) assigned to bivalirudin and 129 (6.5%) assigned to heparin (rate ratio 0.90, 95% confidence interval 0.70 to 1.16; P=0.43), whereas net adverse clinical events occurred in 139 (7.0%) patients assigned to bivalirudin and 163 (8.2%) assigned to heparin (0.84, 0.67 to 1.05; P=0.13). In patients without ST segment elevation, major adverse cardiovascular events occurred in 253 (15.9%) assigned to bivalirudin and 262 (16.4%) assigned to heparin (0.97, 0.80 to 1.17; P=0.74), whereas net adverse clinical events occurred in 262 (16.5%) patients assigned to bivalirudin and 281 (17.6%) ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27677503; info:eu-repo/semantics/altIdentifier/wos/WOS:000385855100001; volume:354; firstpage:1; lastpage:11; numberofpages:11; journal:BMJ; https://hdl.handle.net/11570/3284420Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84995747091; https://www.bmj.com/content/354/bmj.i4935.longTest |
| DOI: | 10.1136/bmj.i4935 |
| الإتاحة: | https://doi.org/10.1136/bmj.i4935Test https://hdl.handle.net/11570/3284420Test https://www.bmj.com/content/354/bmj.i4935.longTest |
| رقم الانضمام: | edsbas.5A7D8358 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/bmj.i4935 |
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