Diffusion-weighted MRI in Advanced Epithelial Ovarian Cancer: Apparent Diffusion Coefficient as a Response Marker.
| العنوان: | Diffusion-weighted MRI in Advanced Epithelial Ovarian Cancer: Apparent Diffusion Coefficient as a Response Marker. |
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| المؤلفون: | Winfield, JM, Wakefield, JC, Dolling, D, Hall, M, Freeman, S, Brenton, JD, Lutchman-Singh, K, Pace, E, Priest, AN, Quest, RA, Taylor, NJ, Gabra, H, McKnight, L, Collins, DJ, Banerjee, S, Hall, E, deSouza, NM |
| المساهمون: | deSouza, Nandita, Winfield, Jessica, Banerjee, Susana, Hall, Emma |
| سنة النشر: | 2020 |
| المجموعة: | The Institute of Cancer Research (ICR): Publications Repository |
| مصطلحات موضوعية: | Humans, Neoplasm Recurrence, Local, Diffusion Magnetic Resonance Imaging, Neoplasm Staging, Combined Modality Therapy, Survival Rate, Prospective Studies, Aged, Middle Aged, Female, Biomarkers, Tumor, Carcinoma, Ovarian Epithelial |
| الوصف: | Background Treatment of advanced epithelial ovarian cancer results in a relapse rate of 75%. Early markers of response would enable optimization of management and improved outcome in both primary and recurrent disease. Purpose To assess the apparent diffusion coefficient (ADC), derived from diffusion-weighted MRI, as an indicator of response, progression-free survival (PFS), and overall survival. Materials and Methods This prospective multicenter trial (from 2012-2016) recruited participants with stage III or IV ovarian, primary peritoneal, or fallopian tube cancer (newly diagnosed, cohort one; relapsed, cohort two) scheduled for platinum-based chemotherapy, with interval debulking surgery in cohort one. Cohort one underwent two baseline MRI examinations separated by 0-7 days to assess ADC repeatability; an additional MRI was performed after three treatment cycles. Cohort two underwent imaging at baseline and after one and three treatment cycles. ADC changes in responders and nonresponders were compared (Wilcoxon rank sum tests). PFS and overall survival were assessed by using a multivariable Cox model. Results A total of 125 participants (median age, 63.3 years [interquartile range, 57.0-70.7 years]; 125 women; cohort one, n = 47; cohort two, n = 78) were included. Baseline ADC (range, 77-258 × 10 -5 mm 2 s -1 ) was repeatable (upper and lower 95% limits of agreement of 12 × 10 -5 mm 2 s -1 [95% confidence interval {CI}: 6 × 10 -5 mm 2 s -1 to 18 × 10 -5 mm 2 s -1 ] and -15 × 10 -5 mm 2 s -1 [95% CI: -21 × 10 -5 mm 2 s -1 to -9 × 10 -5 mm 2 s -1 ]). ADC increased in 47% of cohort two after one treatment cycle, and in 58% and 53% of cohorts one and two, respectively, after three cycles. Percentage change from baseline differed between responders and nonresponders after three cycles (16.6% vs 3.9%; P = .02 [biochemical response definition]; 19.0% vs 6.2%; P = .04 [radiologic definition]). ADC increase after one cycle was associated with longer PFS in cohort two (adjusted hazard ratio, 0.86; 95% CI: 0.75, 0.98; P ... |
| نوع الوثيقة: | other/unknown material |
| وصف الملف: | Print-Electronic; 383; application/pdf |
| اللغة: | English |
| تدمد: | 0033-8419 1527-1315 |
| العلاقة: | Radiology, 2019, 293 (2), pp. 374 - 383; https://repository.icr.ac.uk/handle/internal/3929Test |
| DOI: | 10.1148/radiol.2019190545 |
| الإتاحة: | https://doi.org/10.1148/radiol.2019190545Test https://repository.icr.ac.uk/handle/internal/3929Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.5A76704A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00338419 15271315 |
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| DOI: | 10.1148/radiol.2019190545 |