دورية أكاديمية
HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees.
| العنوان: | HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees. |
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| المؤلفون: | Yates, N.L., deCamp, A.C., Korber, B.T., Liao, H.X., Irene, C., Pinter, A., Peacock, J., Harris, L.J., Sawant, S., Hraber, P., Shen, X., Rerks-Ngarm, S., Pitisuttithum, P., Nitayapan, S., Berman, P.W., Robb, M.L., Pantaleo, G., Zolla-Pazner, S., Haynes, B.F., Alam, S.M., Montefiori, D.C., Tomaras, G.D. |
| المصدر: | Journal of virology, vol. 92, no. 8, pp. e01843-17 |
| سنة النشر: | 2018 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | AIDS Vaccines/genetics, AIDS Vaccines/immunology, Animals, Genetic Variation/immunology, HIV Antibodies/immunology, HIV Envelope Protein gp120/genetics, HIV Envelope Protein gp120/immunology, HIV Infections/genetics, HIV Infections/immunology, HIV-1/genetics, HIV-1/immunology, Humans, Macaca mulatta, HIV-1, antibody, antigenicity, diversity, durability, humoral immunity, vaccine |
| الوصف: | Induction of broadly cross-reactive antiviral humoral responses with the capacity to target globally diverse circulating strains is a key goal for HIV-1 immunogen design. A major gap in the field is the identification of diverse HIV-1 envelope antigens to evaluate vaccine regimens for binding antibody breadth. In this study, we define unique antigen panels to map HIV-1 vaccine-elicited antibody breadth and durability. Diverse HIV-1 envelope glycoproteins were selected based on genetic and geographic diversity to cover the global epidemic, with a focus on sexually acquired transmitted/founder viruses with a tier 2 neutralization phenotype. Unique antigenicity was determined by nonredundancy (Spearman correlation), and antigens were clustered using partitioning around medoids (PAM) to identify antigen diversity. Cross-validation demonstrated that the PAM method was better than selection by reactivity and random selection. Analysis of vaccine-elicited V1V2 binding antibody in longitudinal samples from the RV144 clinical trial revealed the striking heterogeneity among individual vaccinees in maintaining durable responses. These data support the idea that a major goal for vaccine development is to improve antibody levels, breadth, and durability at the population level. Elucidating the level and durability of vaccine-elicited binding antibody breadth needed for protection is critical for the development of a globally efficacious HIV vaccine. IMPORTANCE The path toward an efficacious HIV-1 vaccine will require characterization of vaccine-induced immunity that can recognize and target the highly genetically diverse virus envelope glycoproteins. Antibodies that target the envelope glycoproteins, including diverse sequences within the first and second hypervariable regions (V1V2) of gp120, were identified as correlates of risk for the one partially efficacious HIV-1 vaccine. To build upon this discovery, we experimentally and computationally evaluated humoral responses to define envelope glycoproteins representative of ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0022-538X |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29386288; info:eu-repo/semantics/altIdentifier/eissn/1098-5514; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_7D182EB829216; https://serval.unil.ch/notice/serval:BIB_7D182EB82921Test; urn:issn:0022-538X; https://serval.unil.ch/resource/serval:BIB_7D182EB82921.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_7D182EB829216Test |
| DOI: | 10.1128/JVI.01843-17 |
| الإتاحة: | https://doi.org/10.1128/JVI.01843-17Test https://serval.unil.ch/notice/serval:BIB_7D182EB82921Test https://serval.unil.ch/resource/serval:BIB_7D182EB82921.P001/REF.pdfTest http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_7D182EB829216Test |
| حقوق: | info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.5A550298 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0022538X |
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| DOI: | 10.1128/JVI.01843-17 |